Mechanisms underlying immobilization-induced muscle pain in rats.
Animals
Carbazoles
/ pharmacology
Casts, Surgical
Enzyme Inhibitors
/ pharmacology
Hindlimb
Hyperalgesia
/ metabolism
Immobilization
Indole Alkaloids
/ pharmacology
Interleukin-1beta
/ genetics
Macrophages
/ pathology
Male
Muscle, Skeletal
/ innervation
Nerve Fibers
/ pathology
Nerve Fibers, Unmyelinated
/ pathology
Nerve Growth Factor
/ metabolism
Pain Threshold
/ drug effects
Pressure
RNA, Messenger
/ metabolism
Random Allocation
Rats
Rats, Wistar
Receptor, trkA
/ antagonists & inhibitors
C fiber
M1 macrophage
NGF
immobilization
muscle pain
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
27
04
2019
revised:
01
12
2019
accepted:
03
12
2019
pubmed:
23
2
2020
medline:
7
7
2020
entrez:
22
2
2020
Statut:
ppublish
Résumé
We investigated the mechanisms underlying immobilization-induced muscle pain in rats. In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin-1β (IL-1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels. Immobilization resulted in a decrease in PPT and increases in NGF level, C-fiber density, M1 macrophage number, and IL-1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT. NGF upregulation may be a major contributor to immobilization-induced muscle pain. The increases in C-fiber density, M1 macrophage number, and IL-1β mRNA expression may be related to immobilization-induced muscle pain.
Substances chimiques
Carbazoles
0
Enzyme Inhibitors
0
IL1B protein, rat
0
Indole Alkaloids
0
Interleukin-1beta
0
Ngf protein, rat
0
RNA, Messenger
0
Nerve Growth Factor
9061-61-4
staurosporine aglycone
97161-97-2
Receptor, trkA
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
662-670Informations de copyright
© 2020 Wiley Periodicals, Inc.
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