TERRA, a Multifaceted Regulator of Telomerase Activity at Telomeres.
TERRA
lncRNA
telomerase
telomeres
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
29
10
2019
revised:
06
02
2020
accepted:
10
02
2020
pubmed:
23
2
2020
medline:
23
1
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
In eukaryotes, telomeres are repetitive sequences at the end of chromosomes, which are maintained in a constitutive heterochromatin state. It is now known that telomeres can be actively transcribed, leading to the production of a telomeric repeat-containing noncoding RNA called TERRA. Due to its sequence complementarity to the telomerase template, it was suggested early on that TERRA could be an inhibitor of telomerase. Since then, TERRA has been shown to be involved in heterochromatin formation at telomeres, to invade telomeric dsDNA and form R-loops, and even to promote telomerase recruitment at short telomeres. All these functions depend on the diverse capacities of this lncRNA to bind various cofactors, act as a scaffold, and promote higher-order complexes in cells. In this review, it will be highlighted as to how these properties of TERRA work together to regulate telomerase activity at telomeres.
Identifiants
pubmed: 32084415
pii: S0022-2836(20)30154-6
doi: 10.1016/j.jmb.2020.02.004
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4232-4243Subventions
Organisme : CIHR
ID : MOP-89768
Pays : Canada
Organisme : CIHR
ID : PJT-162156
Pays : Canada
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.