Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.
Aging
/ drug effects
Aldehydes
/ pharmacology
Alzheimer Disease
/ pathology
Animals
Brain
/ drug effects
Cell Line
Cell Respiration
/ drug effects
Cyclopentane Monoterpenes
/ pharmacology
Disease Models, Animal
Female
Glucosides
/ pharmacology
Humans
Mice
Mitochondria
/ drug effects
Neurons
/ drug effects
Neuroprotective Agents
/ pharmacology
Phenols
/ pharmacology
Pyrans
/ pharmacology
Ageing
Mitochondrial dysfunction
Neurodegeneration
Olive secoiridoids
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
31
10
2019
revised:
18
01
2020
accepted:
13
02
2020
pubmed:
23
2
2020
medline:
31
12
2020
entrez:
22
2
2020
Statut:
ppublish
Résumé
As components of the Mediterranean diet (MedDiet) olive polyphenols may play a crucial role for the prevention of Alzheimer's disease (AD). Since mitochondrial dysfunction is involved in both, brain ageing and early AD, effects of 10 different purified phenolic secoiridoids (hydroxytyrosol, tyrosol, oleacein, oleuroside, oleuroside aglycon, oleuropein, oleocanthal, ligstroside, ligstroside aglycone and ligustaloside B) and two metabolites (the plant metabolite elenolic acid and the mammalian metabolite homovanillic acid) were tested in very low doses on mitochondrial function in SH-SY5Y-APP
Identifiants
pubmed: 32084452
pii: S0014-4886(20)30079-0
doi: 10.1016/j.expneurol.2020.113248
pii:
doi:
Substances chimiques
Aldehydes
0
Cyclopentane Monoterpenes
0
Glucosides
0
Neuroprotective Agents
0
Phenols
0
Pyrans
0
ligstroside
83S9SA69C5
oleocanthal
AC7QO6038O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113248Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.