Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination.
Animals
Breast Neoplasms
/ pathology
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cobalt
/ chemistry
Colonic Neoplasms
/ pathology
Disease Models, Animal
Female
Ferric Compounds
/ chemistry
Humans
Hyperthermia, Induced
/ methods
Magnetic Field Therapy
Magnetite Nanoparticles
/ chemistry
Mice
Neoplasm Metastasis
Temperature
Cobalt ferrite nanoparticles
Magnetic hyperthermia
Metastasis
Murine tumor models
Temperature-dependent heating
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
05
08
2019
revised:
30
12
2019
accepted:
03
02
2020
pubmed:
23
2
2020
medline:
26
5
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
Magnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models - breast (4T1) and colon (CT26) cancer in vitro and in vivo. The overall MHT killing capacity in vitro increased with the temperature and CT26 cells were more sensitive than 4T1 when heated to 43 °C. Well in line with the in vitro data, such heating cured non-metastatic CT26 tumors in vivo, while only inhibiting metastatic 4T1 tumor growth without improving the overall survival. High-temperature MHT (>47 °C) resulted in complete 4T1 primary tumor clearance, 25-40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction. Thus, the specific MHT temperature must be defined for each tumor individually to ensure a successful antitumor therapy.
Identifiants
pubmed: 32084594
pii: S1549-9634(20)30023-X
doi: 10.1016/j.nano.2020.102171
pii:
doi:
Substances chimiques
Ferric Compounds
0
Magnetite Nanoparticles
0
cobalt ferrite
0
Cobalt
3G0H8C9362
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102171Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.