Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.
Journal
Journal of neural engineering
ISSN: 1741-2552
Titre abrégé: J Neural Eng
Pays: England
ID NLM: 101217933
Informations de publication
Date de publication:
08 04 2020
08 04 2020
Historique:
pubmed:
23
2
2020
medline:
29
6
2021
entrez:
22
2
2020
Statut:
epublish
Résumé
We report the transcranial functional photoacoustic (fPA) neuroimaging of N-methyl-D-aspartate (NMDA) evoked neural activity in the rat hippocampus. Concurrent quantitative electroencephalography (qEEG) and microdialysis were used to record real-time circuit dynamics and excitatory neurotransmitter concentrations, respectively. We hypothesized that location-specific fPA voltage-sensitive dye (VSD) contrast would identify neural activity changes in the hippocampus which correlate with NMDA-evoked excitatory neurotransmission. Transcranial fPA VSD imaging at the contralateral side of the microdialysis probe provided NMDA-evoked VSD responses with positive correlation to extracellular glutamate concentration changes. qEEG validated a wide range of glutamatergic excitation, which culminated in focal seizure activity after a high NMDA dose. We conclude that transcranial fPA VSD imaging can distinguish focal glutamate loads in the rat hippocampus, based on the VSD redistribution mechanism which is sensitive to the electrophysiologic membrane potential. Our results suggest the future utility of this emerging technology in both laboratory and clinical sciences as an innovative functional neuroimaging modality.
Identifiants
pubmed: 32084654
doi: 10.1088/1741-2552/ab78ca
pmc: PMC7145727
mid: NIHMS1571254
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Glutamic Acid
3KX376GY7L
N-Methylaspartate
6384-92-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
025001Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL139543
Pays : United States
Organisme : NIMH NIH HHS
ID : R24 MH106083
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB001963
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DA000522
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD090884
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA202199
Pays : United States
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