The Vacuolar H

Autophagy / drug effects Carcinoma, Pancreatic Ductal / metabolism Cell Line, Tumor Cell Movement / genetics Cell Proliferation / drug effects Gene Knockdown Techniques Humans Hydrogen-Ion Concentration Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Neoplasm Invasiveness / genetics Pancreatic Neoplasms / metabolism Protease Inhibitors / pharmacology Protein Subunits / genetics Signal Transduction / drug effects Up-Regulation Vacuolar Proton-Translocating ATPases / antagonists & inhibitors
ATP6V0a3 PDAC TCIRG1 autophagy invasion matrix degradation migration pH-regulation proliferation

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
18 02 2020
Historique:
received: 12 12 2019
revised: 10 02 2020
accepted: 13 02 2020
entrez: 23 2 2020
pubmed: 23 2 2020
medline: 20 2 2021
Statut: epublish

Résumé

Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H

Identifiants

DOI: 10.3390/cells9020465 PMID: 32085585 PMC: PMC7072798
pubmed: 32085585
pii: cells9020465
doi: 10.3390/cells9020465
pmc: PMC7072798
pii:
doi:

Substances chimiques

HIF1A protein, human 0
Hypoxia-Inducible Factor 1, alpha Subunit 0
Protease Inhibitors 0
Protein Subunits 0
TCIRG1 protein, human 0
Vacuolar Proton-Translocating ATPases EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Mette Flinck (M)

Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Sofie Hagelund (S)

Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Andrej Gorbatenko (A)

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Marc Severin (M)

Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Elena Pedraz-Cuesta (E)

Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Ivana Novak (I)

Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Christian Stock (C)

Department of Gastroentero-, Hepato- and Endocrinology, Hannover Medical School, D-30625 Hannover, Germany.

Stine Falsig Pedersen (SF)

Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › The Vacuolar H
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › The Vacuolar H
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › The Vacuolar H
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › The Vacuolar H
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › The Vacuolar H
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › The Vacuolar H
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Vacuolar H
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › The Vacuolar H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › The Vacuolar H
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › The Vacuolar H
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › The Vacuolar H
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › The Vacuolar H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sous-unités de protéines › The Vacuolar H
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The Vacuolar H
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › The Vacuolar H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Proton-Translocating ATPases › Vacuolar Proton-Translocating ATPases › The Vacuolar H