Primary characterization of the immune response in pigs infected with Trichinella spiralis.
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
21 Feb 2020
21 Feb 2020
Historique:
received:
12
11
2019
accepted:
20
01
2020
entrez:
23
2
2020
pubmed:
23
2
2020
medline:
26
8
2020
Statut:
epublish
Résumé
Trichinellosis, which is caused by Trichinella spiralis (T. spiralis), is a serious zoonosis. Pigs play an important role in the transmission of human trichinellosis. Characterizing the immune response to T. spiralis infection is key to elucidating host-parasite interactions. However, most studies on the immune response to T. spiralis infection have employed murine models. In this study, we investigated the immune response to T. spiralis infection in pigs. The results showed that the average numbers of larvae per gram (lpg) for the 100-muscle larvae (ML), 1000-ML, and 10 000-ML groups were 1.502, 35.947, and 398.811, respectively. The percentages of CD3+ T cells, B cells, CD4+ T cells, Treg cells, and Th17 cells were elevated in the infection groups compared to the control animals. In contrast, CD8+ T cell percentages were reduced after infection in the low-dose group. The number of neutrophils was increased at 3-17 days post-infection (dpi). Th1 cytokine IL-2 levels were significantly decreased at 7 dpi, and Th2 cytokine IL-4 levels were significantly elevated at 3 dpi. Treg cytokine IL-10 levels were significantly elevated between 7 dpi and 30 dpi. Th17 cytokine IL-17A levels were significantly increased beginning at 11 dpi. These results confirmed that pigs infected with T. spiralis predominantly induced Th2 and Treg immune responses, which suppress the Th1 immune responses. This study provides novel insights into the immune response of pigs infected with T. spiralis.
Identifiants
pubmed: 32085808
doi: 10.1186/s13567-020-0741-0
pii: 10.1186/s13567-020-0741-0
pmc: PMC7035712
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17Subventions
Organisme : The National Key Research and Development Program of China
ID : 2017YFD0501300
Organisme : National Natural Science Foundation of China
ID : 31520103916
Organisme : National Natural Science Foundation of China
ID : 31872467
Organisme : Guangdong Innovative and Enterpreneurial Research Team Program
ID : 2014ZT05S123
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