Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis.
Epstein-Barr virus
Multiple sclerosis
Risk factors
Smoking
Vitamin D
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
16
10
2019
revised:
15
01
2020
accepted:
03
02
2020
pubmed:
23
2
2020
medline:
23
3
2021
entrez:
23
2
2020
Statut:
ppublish
Résumé
The aim of this study was to explore the association between MS and vitamin D levels, as well as Epstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and duration of smoking, sunlight exposure, physical activity, and personal and family history in individuals with and without multiple sclerosis during adolescence. A multivariable logistic regression model was then performed to explore the association between vitamin D status and MS. A total of 87 individuals with MS (mean age 40.9 years; 65.52% females) and 87 without MS (mean age 55 years; 65.52% females) were included in the analysis. In the multivariable analysis, after controlling for supplementation vitamin D levels did not differ between both groups and no difference was found regarding tobacco smoke exposure. The proportion of individuals who tested positive for anti-EBV nuclear antigen was significantly higher in individuals with MS (95.4% vs 82.76%, p = 0.028) CONCLUSION: : We did not find a statistically significant association between MS and vitamin D levels while anti-EBV nuclear antigen titers behaved as previously described in the literature. This study provides new evidence of the association between MS and different risk factors in our country, reinforcing the hypothesis that the pathogenesis of MS is multifactorial. Further studies are needed to better define the association between environmental factors and the development of MS in low prevalence areas.
Identifiants
pubmed: 32086164
pii: S2211-0348(20)30059-6
doi: 10.1016/j.msard.2020.101983
pii:
doi:
Substances chimiques
Epstein-Barr Virus Nuclear Antigens
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101983Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest J. Toro is an associate editor of NEJM Journal Watch Neurology and is an editorial board member for Multiple Sclerosis and Related Disorders. L. Burbano, S. Reyes, D. F. Cuellar-Giraldo, A. Duque, M. I. Reyes-Mantilla, C. Torres, J. Ríos, J. S. Rivera, F. Cortés, J. Patiño, and D. Noriega report no disclosures.