Biochemical characterization of acyl activating enzymes for side chain moieties of Taxol and its analogs.
CoA ligase
Taxol
Taxus
acyl-activating enzyme
coenzyme A (CoA)
metabolism
natural product biosynthesis
paclitaxel
plant biochemistry
terpenoid
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
10 04 2020
10 04 2020
Historique:
received:
22
01
2020
revised:
14
02
2020
pubmed:
23
2
2020
medline:
15
12
2020
entrez:
23
2
2020
Statut:
ppublish
Résumé
Taxol (paclitaxel) is a very widely used anticancer drug, but its commercial sources mainly consist of stripped bark or suspension cultures of members of the plant genus Taxus. Taxol accumulates as part of a complex mixture of chemical analogs, termed taxoids, which complicates its production in pure form, highlighting the need for metabolic engineering approaches for high-level Taxol production in cell cultures or microbial hosts. Here, we report on the characterization of acyl-activating enzymes (AAEs) that catalyze the formation of CoA esters of different organic acids relevant for the
Identifiants
pubmed: 32086380
pii: S0021-9258(17)48591-7
doi: 10.1074/jbc.RA120.012663
pmc: PMC7152758
doi:
Substances chimiques
Acyl Coenzyme A
0
Esters
0
Recombinant Proteins
0
Coenzyme A Ligases
EC 6.2.1.-
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4963-4973Subventions
Organisme : NCCIH NIH HHS
ID : R01 AT010593
Pays : United States
Organisme : NIGMS NIH HHS
ID : RC2 GM092561
Pays : United States
Informations de copyright
© 2020 Srividya et al.
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