An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease.
Acute Disease
Adolescent
Adult
Allografts
Bacteroidetes
/ isolation & purification
Bone Marrow Transplantation
/ adverse effects
Cord Blood Stem Cell Transplantation
/ adverse effects
Dysbiosis
/ genetics
Female
Gastrointestinal Microbiome
Graft vs Host Disease
/ genetics
Humans
Male
Metagenome
Paneth Cells
/ metabolism
Peripheral Blood Stem Cell Transplantation
/ adverse effects
Polymorphism, Single Nucleotide
Risk
Symbiosis
Young Adult
alpha-Defensins
/ genetics
odoribacter
graft-versus-host disease
microbiota
paneth cell
polymorphism
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
29
09
2019
revised:
30
11
2019
accepted:
02
12
2019
pubmed:
23
2
2020
medline:
28
1
2021
entrez:
23
2
2020
Statut:
ppublish
Résumé
We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri-engraftment presence of O. splanchnicus was associated with ~50% lower risk for grade II-IV aGVHD (hazard ratio 0·53, 95% confidence interval 0·28-1·00, P = 0·05). O. splanchnicus may protect rs4415345G individuals against aGVHD.
Identifiants
pubmed: 32086815
doi: 10.1111/bjh.16458
pmc: PMC7536617
mid: NIHMS1632433
doi:
Substances chimiques
DEFA5 protein, human
0
alpha-Defensins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
926-930Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002494
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118979
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI034495
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002492
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL143189
Pays : United States
Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
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