Risk factors for equine recurrent uveitis in a population of Appaloosa horses in western Canada.
Appaloosa
ERU
TRPM1
genotype
leopard complex
uveitis
Journal
Veterinary ophthalmology
ISSN: 1463-5224
Titre abrégé: Vet Ophthalmol
Pays: England
ID NLM: 100887377
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
13
08
2019
revised:
22
01
2020
accepted:
23
01
2020
pubmed:
23
2
2020
medline:
11
2
2021
entrez:
23
2
2020
Statut:
ppublish
Résumé
To characterize clinical manifestations, measure frequency, and evaluate risk factors for equine recurrent uveitis (ERU) in Appaloosa horses in western Canada. 145 Appaloosa horses. Ophthalmic examinations were completed and eyes were classified as having no or mild clinical signs, or moderate, or severe damage from ERU. Clinical signs, age, sex, base coat color, and pattern were recorded. Whole blood and/or mane hair follicles were collected for DNA extraction, and all horses were tested for the leopard complex (LP) spotting pattern allele. Pedigree analysis was completed on affected and unaffected horses, and coefficients of coancestry (CC) and inbreeding (COI) were determined. Equine recurrent uveitis was confirmed in 20 (14%) horses. The mean age of affected horses was 12.3 years (±5.3; range 3-25). Age was a significant risk factor for ERU diagnosis (OR Age, coat pattern, and genetics are major risk factors for the diagnosis and classification of ERU in the Appaloosa.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-525Informations de copyright
© 2020 American College of Veterinary Ophthalmologists.
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