Targeting apoptotic caspases in cancer.
Apoptosis
Cancer
Caspase
IAPs
Mitochondria
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
16
09
2019
revised:
20
01
2020
accepted:
15
02
2020
pubmed:
23
2
2020
medline:
8
8
2020
entrez:
23
2
2020
Statut:
ppublish
Résumé
Members of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis. Many conventional cancer therapies induce apoptosis to remove the cancer cell by engaging these caspases indirectly. Newer therapeutic applications have been designed, including those that specifically activate individual caspases using gene therapy approaches and small molecules that repress natural inhibitors of caspases already present in the cell. For such approaches to have maximal clinical efficacy, emerging insights into non-apoptotic roles of these caspases need to be considered. This review will discuss the roles of caspases as safeguards against cancer in the context of the advantages and potential limitations of targeting apoptotic caspases for the treatment of cancer.
Identifiants
pubmed: 32087180
pii: S0167-4889(20)30046-X
doi: 10.1016/j.bbamcr.2020.118688
pmc: PMC7155770
mid: NIHMS1570057
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118688Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM121389
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA256606
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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