The role and function of long non-coding RNAs in osteoarthritis.

Cartilage, Articular / metabolism Chondrocytes / metabolism Humans Inflammation / genetics Osteoarthritis / genetics RNA, Long Noncoding / genetics
Joint disease Long non-coding RNA OA Osteoarthritis lncRNA

Journal

Experimental and molecular pathology
ISSN: 1096-0945
Titre abrégé: Exp Mol Pathol
Pays: Netherlands
ID NLM: 0370711

Informations de publication

Date de publication:
06 2020
Historique:
received: 09 07 2019
revised: 03 01 2020
accepted: 19 02 2020
pubmed: 24 2 2020
medline: 28 10 2020
entrez: 24 2 2020
Statut: ppublish

Résumé

Osteoarthiritis (OA) is the most prevalent disease of articulating joints in human that frequently results in joint pain, movement limitations, inflammation, and progressive degradation of articular cartilage. The etiology of OA is not completely clear and there is no full treatment for this disease. Molecular investigations have revealed the involvement of non-coding RNAs such as Long non-coding RNAs (lncRNAs) in OA pathogenesis. LncRNAs play roles in multiple cellular and biological processes. Moreover, numerous lncRNAs are differentially expressed in human OA cartilage. In this review, we underlie the increasing evidence for the critical role of lncRNAs in OA pathogenesis reviewing the latest researches.

Identifiants

DOI: 10.1016/j.yexmp.2020.104407 PMID: 32088191
pubmed: 32088191
pii: S0014-4800(19)30529-5
doi: 10.1016/j.yexmp.2020.104407
pii:
doi:

Substances chimiques

RNA, Long Noncoding 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104407

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Auteurs

Mitra Abbasifard (M)

Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Zahra Kamiab (Z)

Department of Family Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Clinical Research Development Unit, Ali Ibn Abi Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Zahra Bagheri-Hosseinabadi (Z)

Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address: baghery.zahra@yahoo.com.

Iman Sadeghi (I)

Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, Barcelona, E-08003 Catalonia, Spain; CEINGE-biotecnologie avanzate, Naples, Italy. Electronic address: iman.sadeghi@crg.eu.

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Classifications MeSH

questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Cartilage articulaire › The role and function of long non-coding RNAs...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › The role and function of long non-coding RNAs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The role and function of long non-coding RNAs...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The role and function of long non-coding RNAs...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › The role and function of long non-coding RNAs...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › The role and function of long non-coding RNAs...