Targeting prostaglandin receptor EP2 for adjunctive treatment of status epilepticus.
EP2
Epilepsy
Neuroinflammation
Prostaglandin
Seizures
Status epilepticus
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
02
12
2019
accepted:
27
01
2020
pubmed:
24
2
2020
medline:
10
4
2021
entrez:
24
2
2020
Statut:
ppublish
Résumé
Status epilepticus (SE) is an emergency condition that can cause permanent brain damage or even death when generalized convulsive seizures last longer than 30 min. Controlling the escalation and propagation of seizures quickly and properly is crucial to the prevention of irreversible neuronal death and the associated morbidity. However, SE often becomes refractory to current anticonvulsant medications, which primarily act on ion channels and commonly impose undesired effects. Identifying new molecular targets for SE might lead to adjunctive treatments that can be delivered even when SE is well established. Recent preclinical studies suggest that prostaglandin E2 (PGE
Identifiants
pubmed: 32088247
pii: S0163-7258(20)30032-2
doi: 10.1016/j.pharmthera.2020.107504
pmc: PMC7222917
mid: NIHMS1568736
pii:
doi:
Substances chimiques
Anticonvulsants
0
Neuroprotective Agents
0
Receptors, Prostaglandin E, EP2 Subtype
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107504Subventions
Organisme : NINDS NIH HHS
ID : R00 NS082379
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100947
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS109687
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflict of interest to declare.
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