Synchrotron X-Ray Boost Delivered by Microbeam Radiation Therapy After Conventional X-Ray Therapy Fractionated in Time Improves F98 Glioma Control.
Animals
Brain Neoplasms
/ diagnostic imaging
Cell Cycle
/ radiation effects
Cell Proliferation
/ radiation effects
Dose Fractionation, Radiation
Glioblastoma
/ diagnostic imaging
Glioma
/ radiotherapy
Magnetic Resonance Imaging
Male
Rats
Rats, Wistar
Synchrotrons
Tumor Burden
/ radiation effects
X-Ray Therapy
/ instrumentation
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
05
09
2019
revised:
29
01
2020
accepted:
02
02
2020
pubmed:
24
2
2020
medline:
13
2
2021
entrez:
24
2
2020
Statut:
ppublish
Résumé
Synchrotron microbeam radiation therapy (MRT) is based on the spatial fractionation of the incident, highly collimated synchrotron beam into arrays of parallel microbeams depositing several hundred grays. It appears relevant to combine MRT with a conventional treatment course, preparing a treatment scheme for future patients in clinical trials. The efficiency of MRT delivered after several broad-beam (BB) fractions to palliate F98 brain tumors in rats in comparison with BB fractions alone was evaluated in this study. Rats bearing 10 MRT-boosted tumors displayed lower cell density and cell proliferation compared with BB-irradiated tumors. The MRT boost completely stopped tumor growth during ∼4 weeks and led to a significant increase in median survival time, whereas tumors treated with BB alone recurred within a few days after the last radiation fraction. The first evidence is presented that MRT, delivered as a boost of conventionally fractionated irradiation by orthovoltage broad x-ray beams, is feasible and more efficient than conventional radiation therapy alone.
Identifiants
pubmed: 32088292
pii: S0360-3016(20)30222-4
doi: 10.1016/j.ijrobp.2020.02.023
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
360-369Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.