Collection of Peripheral Blood Progenitor Cells in 1 Day Is Associated with Decreased Donor Toxicity Compared to 2 Days in Unrelated Donors.
Apheresis
Donor toxicity
Unrelated donor
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
21
11
2019
revised:
29
01
2020
accepted:
10
02
2020
pubmed:
24
2
2020
medline:
24
6
2021
entrez:
24
2
2020
Statut:
ppublish
Résumé
Peripheral blood stem cells (PBSCs) have been increasingly used for allogeneic hematopoietic cell transplantation instead of bone marrow stem cells. Current National Marrow Donor Program policy recommends 5 days of daily filgrastim, followed by either 1 or 2 days of apheresis for unrelated donors, depending on collection center choice. To date, there are no published studies comparing the differences in donor experience between 1 day and 2 days of apheresis. We examined 22,348 adult unrelated donor collections in 184 centers between 2006 and 2016. Of these 22,348 donors, 20,004 (89.5%) had collection on 1 day, and the other 2344 (9.5%) had collection over 2 days. Information on why donors underwent apheresis in 1 day or 2 days was not available. Donors who underwent apheresis in 1 day were more likely to be male (67% versus 46%; P < .001), younger (age <30 years, 48% versus 36%; P < .001), and have a higher body weight (83.0 kg versus 75.9 kg; P< .001) and body mass index (BMI; >30, 30% versus 22%; P < .001). Successful collection of the requested CD34
Identifiants
pubmed: 32088366
pii: S1083-8791(20)30096-3
doi: 10.1016/j.bbmt.2020.02.011
pmc: PMC7347029
mid: NIHMS1589932
pii:
doi:
Substances chimiques
Antigens, CD34
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1210-1217Subventions
Organisme : NCI NIH HHS
ID : U24 CA076518
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
Blood. 1995 Mar 15;85(6):1659-65
pubmed: 7888684
J Clin Apher. 1999;14(1):18-25
pubmed: 10355659
Br J Haematol. 2003 Mar;120(5):801-7
pubmed: 12614213
Blood. 2009 Oct 29;114(18):3757-63
pubmed: 19666868
J Clin Apher. 2003;18(1):10-5
pubmed: 12717787
Blood. 1995 Mar 15;85(6):1655-8
pubmed: 7534140
Blood. 2014 Jun 5;123(23):3655-63
pubmed: 24735965
Blood. 2009 Apr 9;113(15):3604-11
pubmed: 19190248
Bone Marrow Transplant. 2001 Apr;27(7):689-92
pubmed: 11360107
Transfusion. 2000 Nov;40(11):1363-70
pubmed: 11099666
Transfusion. 2000 Apr;40(4):493-5
pubmed: 10773065
Haematologica. 2009 Jan;94(1):94-101
pubmed: 19059940
Vox Sang. 2005 Nov;89(4):229-35
pubmed: 16262756
Nature. 2008 Mar 27;452(7186):442-7
pubmed: 18256599
Blood. 2013 Jan 3;121(1):197-206
pubmed: 23109243
Blood. 1995 Mar 15;85(6):1666-72
pubmed: 7534141
Bone Marrow Transplant. 2008 Aug;42 Suppl 1:S1-S2
pubmed: 18724277
Transfusion. 1999 Apr;39(4):403-9
pubmed: 10220268
Cell Stem Cell. 2008 Oct 9;3(4):364-6
pubmed: 18940728