Combined targeting of EGFR and HER2 against prostate cancer stem cells.
Animals
Antineoplastic Combined Chemotherapy Protocols
/ pharmacology
Cell Line, Tumor
Cetuximab
/ administration & dosage
Docetaxel
/ administration & dosage
ErbB Receptors
/ antagonists & inhibitors
Humans
Male
Mice
Mice, SCID
Neoplastic Stem Cells
/ drug effects
Prostatic Neoplasms
/ drug therapy
Prostatic Neoplasms, Castration-Resistant
/ drug therapy
Receptor, ErbB-2
/ antagonists & inhibitors
Trastuzumab
/ administration & dosage
Xenograft Model Antitumor Assays
EGFR
HER2
Prostate
cancer stem cells
chemotherapy
Journal
Cancer biology & therapy
ISSN: 1555-8576
Titre abrégé: Cancer Biol Ther
Pays: United States
ID NLM: 101137842
Informations de publication
Date de publication:
03 05 2020
03 05 2020
Historique:
pubmed:
25
2
2020
medline:
17
12
2020
entrez:
25
2
2020
Statut:
ppublish
Résumé
Progression of prostate cancer has been associated with EGFR and HER2 activation and to tumor-initiating cells contribution toward chemotherapy resistance. We investigated the efficacy of a dual intervention against EGFR and HER2 to deplete the tumor-initiating cells, optimize the chemotherapy management and prevent the progression of castration-resistant prostate cancer (CRPC) cells. Using DU145, PC3, and 22Rv1 CRPC cell lines, biochemical analysis revealed activation of EGFR, HER2, MAPK, and STAT3 in DU145 and 22Rv1, and AKT and SRC in DU145 and PC-3. pSTAT3 nuclear staining was observed in DU145 xenografts and in 12 out of 14 CRPC specimens. The
Identifiants
pubmed: 32089070
doi: 10.1080/15384047.2020.1727702
pmc: PMC7515488
doi:
Substances chimiques
Docetaxel
15H5577CQD
EGFR protein, human
EC 2.7.10.1
ERBB2 protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Trastuzumab
P188ANX8CK
Cetuximab
PQX0D8J21J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
463-475Références
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