PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.
Journal
Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
14
08
2019
accepted:
30
01
2020
revised:
30
12
2019
pubmed:
25
2
2020
medline:
20
11
2020
entrez:
25
2
2020
Statut:
ppublish
Résumé
In classical Hodgkin lymphoma (cHL)-characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells-tumor-associated macrophages (TAMs) play a pivotal role in tumor formation. However, the significance of direct contact between HRS cells and TAMs has not been elucidated. HRS cells and TAMs are known to express PD-L1, which leads to PD-1
Identifiants
pubmed: 32089543
doi: 10.1038/s41375-020-0737-9
pii: 10.1038/s41375-020-0737-9
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
PDCD1LG2 protein, human
0
Programmed Cell Death 1 Ligand 2 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2405-2417Subventions
Organisme : MEXT | JST | Precursory Research for Embryonic Science and Technology (PRESTO)
ID : AMED-PRIME
Pays : International
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