Production of functional mimics of human milk oligosaccharides by enzymatic glycosylation of bovine milk oligosaccharides.
Journal
International dairy journal
ISSN: 0958-6946
Titre abrégé: Int Dairy J
Pays: England
ID NLM: 101213739
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
25
2
2020
pubmed:
25
2
2020
medline:
25
2
2020
Statut:
ppublish
Résumé
Consumption of mothers' milk is associated with reduced incidence and severity of enteric infections, leading to reduced morbidity in breastfed infants. Fucosylated and sialylated human milk oligosaccharides (HMO) are important for both direct antimicrobial action - likely via a decoy effect - and indirect antimicrobial action through commensal growth enhancement. Bovine milk oligosaccharides (BMO) are a potential source of HMO-mimics as BMO resemble HMO; however, they have simpler and less fucosylated structures. BMO isolated at large scales from bovine whey permeate were modified by the addition of fucose and/or sialic acid to generate HMO-like glycans using high-yield and cost-effective one-pot multienzyme approaches. Quadrupole time-of-flight LC/MS analysis revealed that 22 oligosaccharides were synthesized and 9 had identical composition to known HMO. Preliminary anti-adherence activity assays indicated that fucosylated BMO decreased the uptake of enterohemorrhagic
Identifiants
pubmed: 32089591
doi: 10.1016/j.idairyj.2019.104583
pmc: PMC7034812
mid: NIHMS1543022
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCCIH NIH HHS
ID : R01 AT008759
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD065122
Pays : United States
Organisme : NICHD NIH HHS
ID : R43 HD083981
Pays : United States
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