Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.
CuAAC
HIV-1
HIV-1 capsid protein
Molecular dynamics simulation
Phenylalanine derivatives
SAR
Surface plasmon resonance
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
25
2
2020
pubmed:
25
2
2020
medline:
25
2
2020
Statut:
ppublish
Résumé
The HIV-1 capsid (CA) protein plays crucial roles in both early and late stages of the viral life cycle, which has intrigued researchers to target it to develop anti-HIV drugs. Accordingly, in this research, we report the design, synthesis and biological evaluation of a series of novel phenylalanine derivatives as HIV-1 CA protein inhibitors using the Cu(I)-catalyzed azide and alkyne 1,3-dipolar cycloaddition (CuAAC) reaction. Among this series of inhibitors, compound
Identifiants
pubmed: 32089839
doi: 10.1039/c9ra05869a
pmc: PMC7034945
mid: NIHMS1051249
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28961-28986Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM125396
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH079785
Pays : United States
Déclaration de conflit d'intérêts
Notes The authors declare no competing financial interest.
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