Daytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea.
Journal
Sleep disorders
ISSN: 2090-3545
Titre abrégé: Sleep Disord
Pays: United States
ID NLM: 101600304
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
09
2019
accepted:
11
01
2020
entrez:
25
2
2020
pubmed:
25
2
2020
medline:
25
2
2020
Statut:
epublish
Résumé
Obstructive sleep apnea (OSA) has been linked to sudden cardiac death (SCD). Prolonged QT is a recognized electrocardiographic (ECG) marker of abnormal ventricular repolarization linked to increased risk of SCD. We hypothesized that individuals with OSA have more pronounced abnormality in daytime QT interval. We reviewed consecutive patients who underwent clinically indicated polysomnography with 12-lead ECG within 1 year at a single center. Heart rate-corrected QT interval (QTc) was compared by OSA severity class (normal/mild: apnea-hypopnea index (AHI) < 15/hr ( A total of 249 patients were included. QTc was similar between the normal/mild and moderate groups, and the overall QTc trend increased across OSA (normal/mild: 435.6 ms; moderate: 431.36; severe: 444.4; In a sleep clinic cohort, severe OSA was associated with higher QTc and clinically defined abnormal QTc compared with nonsevere OSA.
Sections du résumé
BACKGROUND
BACKGROUND
Obstructive sleep apnea (OSA) has been linked to sudden cardiac death (SCD). Prolonged QT is a recognized electrocardiographic (ECG) marker of abnormal ventricular repolarization linked to increased risk of SCD. We hypothesized that individuals with OSA have more pronounced abnormality in daytime QT interval.
METHODS
METHODS
We reviewed consecutive patients who underwent clinically indicated polysomnography with 12-lead ECG within 1 year at a single center. Heart rate-corrected QT interval (QTc) was compared by OSA severity class (normal/mild: apnea-hypopnea index (AHI) < 15/hr (
RESULTS
RESULTS
A total of 249 patients were included. QTc was similar between the normal/mild and moderate groups, and the overall QTc trend increased across OSA (normal/mild: 435.6 ms; moderate: 431.36; severe: 444.4;
CONCLUSIONS
CONCLUSIONS
In a sleep clinic cohort, severe OSA was associated with higher QTc and clinically defined abnormal QTc compared with nonsevere OSA.
Identifiants
pubmed: 32089892
doi: 10.1155/2020/3029836
pmc: PMC7025071
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3029836Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL140432
Pays : United States
Informations de copyright
Copyright © 2020 McCall Walker et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
Sleep. 2015 Jul 01;38(7):1113-9
pubmed: 26118557
Sleep Breath. 2015 Dec;19(4):1135-40
pubmed: 25737301
Am J Cardiol. 1983 Jul;52(1):55-9
pubmed: 6858927
Sleep Med Rev. 2018 Jun;39:134-142
pubmed: 29029984
N Engl J Med. 2005 Mar 24;352(12):1206-14
pubmed: 15788497
Sleep. 2013 Oct 01;36(10):1409-11
pubmed: 24082296
Cardiology. 2011;118(1):68-73
pubmed: 21454976
Heart. 2003 Nov;89(11):1363-72
pubmed: 14594906
J Am Coll Cardiol. 2002 Jun 5;39(11):1820-6
pubmed: 12039498
Am J Cardiol. 2003 Apr 1;91(7):916-9
pubmed: 12667592
Circ Res. 2018 Jun 8;122(12):1741-1764
pubmed: 29880501
Arch Intern Med. 2004 May 10;164(9):943-8
pubmed: 15136301
Eur Respir J. 2006 Sep;28(3):596-602
pubmed: 16641120
Pacing Clin Electrophysiol. 2012 Aug;35(8):966-72
pubmed: 22671991
Am J Cardiol. 1992 Feb 1;69(4):339-43
pubmed: 1734645
Circ Arrhythm Electrophysiol. 2017 Feb;10(2):e004609
pubmed: 28213507
Ann Noninvasive Electrocardiol. 2018 Nov;23(6):e12579
pubmed: 29963729
Eur J Heart Fail. 2000 Sep;2(3):265-71
pubmed: 10938487
Circulation. 1998 Feb 10;97(5):467-72
pubmed: 9490242
Eur Heart J. 2012 Sep;33(17):2206-12
pubmed: 22453648
Cardiol Young. 2011 Apr;21(2):130-5
pubmed: 21070692
Proc Am Thorac Soc. 2008 Feb 15;5(2):136-43
pubmed: 18250205
Am J Med Sci. 2012 Sep;344(3):180-5
pubmed: 22104432
J Am Coll Cardiol. 2013 Aug 13;62(7):610-6
pubmed: 23770166
Circulation. 1991 Jun;83(6):1888-94
pubmed: 2040041
Thorax. 2005 Sep;60(9):781-5
pubmed: 15994252
JAMA. 2000 Dec 20;284(23):3015-21
pubmed: 11122588
Sleep. 1991 Aug;14(4):346-50
pubmed: 1947598