Untargeted metabolomics links glutathione to bacterial cell cycle progression.


Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
02 2020
Historique:
entrez: 25 2 2020
pubmed: 25 2 2020
medline: 25 2 2020
Statut: ppublish

Résumé

Cell cycle progression requires the coordination of cell growth, chromosome replication, and division. Consequently, a functional cell cycle must be coupled with metabolism. However, direct measurements of metabolome dynamics remained scarce, in particular in bacteria. Here, we describe an untargeted metabolomics approach with synchronized

Identifiants

pubmed: 32090198
doi: 10.1038/s42255-019-0166-0
pmc: PMC7035108
mid: EMS85252
pii: 10.1038/s42255-019-0166-0
doi:

Substances chimiques

Glutathione GAN16C9B8O
Potassium RWP5GA015D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

153-166

Subventions

Organisme : Swiss National Science Foundation
ID : 147090
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 173094
Pays : Switzerland

Déclaration de conflit d'intérêts

Competing interest statement The authors declare no competing interest.

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Auteurs

Johannes Hartl (J)

ETH Zurich, Institute of Microbiology, Zurich, Switzerland. hartlj@ethz.ch.

Patrick Kiefer (P)

ETH Zurich, Institute of Microbiology, Zurich, Switzerland.

Andreas Kaczmarczyk (A)

Biozentrum of the University of Basel, Basel, Switzerland.

Maximilian Mittelviefhaus (M)

ETH Zurich, Institute of Microbiology, Zurich, Switzerland.

Fabian Meyer (F)

ETH Zurich, Institute of Microbiology, Zurich, Switzerland.

Thomas Vonderach (T)

ETH Zurich, Laboratory of Inorganic Chemistry, Zurich, Switzerland.

Bodo Hattendorf (B)

ETH Zurich, Laboratory of Inorganic Chemistry, Zurich, Switzerland.

Urs Jenal (U)

Biozentrum of the University of Basel, Basel, Switzerland.

Julia A Vorholt (JA)

ETH Zurich, Institute of Microbiology, Zurich, Switzerland. jvorholt@ethz.ch.

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Classifications MeSH