Men and women differ in the neural basis of handwriting.
Exner's area
fMRI
handwriting
sex differences
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
26
11
2019
revised:
12
02
2020
accepted:
13
02
2020
pubmed:
25
2
2020
medline:
9
11
2021
entrez:
25
2
2020
Statut:
ppublish
Résumé
There is an ongoing debate about whether, and to what extent, males differ from females in their language skills. In the case of handwriting, a composite language skill involving language and motor processes, behavioral observations consistently show robust sex differences but the mechanisms underlying the effect are unclear. Using functional magnetic resonance imaging (fMRI) in a copying task, the present study examined the neural basis of sex differences in handwriting in 53 healthy adults (ages 19-28, 27 males). Compared to females, males showed increased activation in the left posterior middle frontal gyrus (Exner's area), a region thought to support the conversion between orthographic and graphomotor codes. Functional connectivity between Exner's area and the right cerebellum was greater in males than in females. Furthermore, sex differences in brain activity related to handwriting were independent of language material. This study identifies a novel neural signature of sex differences in a hallmark of human behavior, and highlights the importance of considering sex as a factor in scientific research and clinical applications involving handwriting.
Identifiants
pubmed: 32090433
doi: 10.1002/hbm.24968
pmc: PMC7294055
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2642-2655Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
Références
Brain Lang. 2000 Sep;74(2):157-70
pubmed: 10950912
Arch Sex Behav. 1995 Aug;24(4):395-407
pubmed: 7661655
Brain Lang. 2006 Aug;98(2):150-8
pubmed: 16716389
Front Psychol. 2014 Feb 18;5:120
pubmed: 24600420
J Neurosci. 2010 Sep 1;30(35):11576-85
pubmed: 20810879
Am Psychol. 2005 Sep;60(6):581-592
pubmed: 16173891
Percept Mot Skills. 2002 Apr;94(2):623-62
pubmed: 12027360
Cereb Cortex. 2020 Mar 14;30(3):1528-1537
pubmed: 31512720
Brain Lang. 2016 Aug;159:118-26
pubmed: 27393929
Am Psychol. 2019 May-Jun;74(4):445-458
pubmed: 30234314
PLoS One. 2013;8(3):e57988
pubmed: 23516422
Neuroimage. 2016 Apr 1;129:105-116
pubmed: 26777478
Hum Brain Mapp. 2011 Feb;32(2):240-8
pubmed: 20336688
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8781-5
pubmed: 15939871
J Child Psychol Psychiatry. 2017 Jun;58(6):719-727
pubmed: 28176347
Neuroimage. 2007 Nov 15;38(3):402-12
pubmed: 17878070
Nat Rev Neurosci. 2017 Dec;18(12):707-708
pubmed: 29097784
Read Writ. 2015 Oct;28(8):1119-1153
pubmed: 26336330
Neuroimage. 2012 Oct 15;63(1):381-91
pubmed: 22759996
Cogn Neuropsychol. 2009 Feb;26(1):91-110
pubmed: 18830859
J Soc Psychol. 1996 Dec;136(6):778-82
pubmed: 9043207
Front Psychol. 2011 Oct 11;2:239
pubmed: 22013427
Neuropsychologia. 2018 Jun;114:19-31
pubmed: 29654881
Int J Psychophysiol. 2007 Feb;63(2):192-8
pubmed: 16797758
Neuropsychologia. 2007 Mar 2;45(4):741-7
pubmed: 16999980
Neuroimage. 2001 Nov;14(5):1105-21
pubmed: 11697942
Brain. 1990 Jun;113 ( Pt 3):749-66
pubmed: 2364267
Neurology. 2011 Apr 12;76(15):1322-9
pubmed: 21368285
Hum Brain Mapp. 2001 May;13(1):34-42
pubmed: 11284045
J Cogn Neurosci. 2011 Dec;23(12):4067-81
pubmed: 21812571
Cortex. 2017 Mar;88:66-80
pubmed: 28081451
Brain Lang. 2013 Feb;124(2):184-93
pubmed: 23376366
Brain Lang. 2003 Feb;84(2):264-72
pubmed: 12590915
Dev Psychol. 2004 Nov;40(6):993-1027
pubmed: 15535753
Dev Psychol. 2001 Nov;37(6):886-99
pubmed: 11699761
Neuroimage. 2009 Apr 15;45(3):1020-32
pubmed: 19162200
Neuroimage. 2005 Mar;25(1):181-92
pubmed: 15734354
Cortex. 2013 Jul-Aug;49(7):1910-21
pubmed: 22980918
Front Behav Neurosci. 2018 Nov 30;12:288
pubmed: 30555308
Magn Reson Med. 2010 May;63(5):1144-53
pubmed: 20432285
Cortex. 1993 Mar;29(1):115-34
pubmed: 8472549
Ann Neurol. 2009 Oct;66(4):537-45
pubmed: 19847902
Arch Clin Neuropsychol. 2009 Mar;24(2):153-63
pubmed: 19185449
Neuroimage. 2012 Jul 16;61(4):1277-86
pubmed: 22484411
Brain. 2000 May;123 ( Pt 5):954-67
pubmed: 10775540
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20762-7
pubmed: 23184998
Neuroimage. 2013 Dec;83:690-703
pubmed: 23845427
J Cogn Neurosci. 2011 May;23(5):1180-97
pubmed: 20433242
Neuroimage. 1997 Oct;6(3):218-29
pubmed: 9344826
Hum Brain Mapp. 2014 Dec;35(12):6077-87
pubmed: 25093278
Front Hum Neurosci. 2018 Feb 13;12:30
pubmed: 29487511
PLoS One. 2016 Dec 16;11(12):e0168414
pubmed: 27992505
Hum Mov Sci. 2015 Aug;42:161-82
pubmed: 26037277
J Genet Psychol. 2015 May-Aug;176(3-4):211-34
pubmed: 26135387
Nature. 1995 Feb 16;373(6515):607-9
pubmed: 7854416
J Neurosci Methods. 2007 Jun 15;163(1):128-36
pubmed: 17386945
Neuroscience. 1982 Feb;7(2):431-7
pubmed: 7078732
Cognition. 2013 May;127(2):235-41
pubmed: 23454797
Neuroimage. 2007 Sep 1;37(3):912-26
pubmed: 17629502
Neuropsychopharmacology. 2017 Jan;42(2):386-396
pubmed: 27658485
Cognition. 2015 Mar;136:325-36
pubmed: 25525970
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2636-41
pubmed: 9482939
Neurosci Lett. 2003 Apr 3;340(1):13-6
pubmed: 12648747
Front Hum Neurosci. 2014 Mar 19;8:155
pubmed: 24678293
Brain. 2004 Aug;127(Pt 8):1845-52
pubmed: 15240433
Hum Brain Mapp. 2020 Jul;41(10):2642-2655
pubmed: 32090433
Am Psychol. 2015 Jan;70(1):10-20
pubmed: 25581005
Neuropsychologia. 2008 Apr;46(5):1349-62
pubmed: 18262207
Am Psychol. 1997 Oct;52(10):1091-102
pubmed: 9329293
Behav Neurol. 2007;18(2):99-114
pubmed: 17538196
Hum Brain Mapp. 2007 May;28(5):450-9
pubmed: 16944477
Cortex. 2013 Nov-Dec;49(10):2772-87
pubmed: 23831432