Cerebrovascular reactivity to carbon dioxide is not influenced by variability in the ventilatory sensitivity to carbon dioxide.
CO2 reactivity
cerebral blood flow
hypercapnia
ventilation
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
17
09
2019
accepted:
20
02
2020
pubmed:
25
2
2020
medline:
9
9
2021
entrez:
25
2
2020
Statut:
ppublish
Résumé
What is the central question of this study? Do differing magnitudes of ventilation influence cerebrovascular CO Recent work demonstrated an influence of ventilation on cerebrovascular reactivity to CO
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-915Subventions
Organisme : Canada Research Chairs
ID : F16-02798
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
Références
Ainslie, P. N., & Duffin, J. (2009). Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: Mechanisms of regulation, measurement, and interpretation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 296, R1473-R1495.
Ainslie, P. N., Lucas, S. J. E., Fan, J-L., Thomas, K. N., Cotter, J. D., Tzeng, Y. C., & Burgess, K. R. (2012). Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. Journal of Applied Physiology, 113, 1058-1067.
Duffin, J. (2011). Measuring the respiratory chemoreflexes in humans. Respiratory Physiology & Neurobiology, 177, 71-79.
Evans, D. (1985). On the measurement of the mean velocity of blood flow over the cardiac cycle using Doppler ultrasound. Ultrasound in Medicine & Biology, 11, 735-741.
Fan, J. L., Burgess, K. R., Thomas, K. N., Peebles, K. C., Lucas, S. J. E., Lucas, R. A. I.,& Ainslie, P. N. (2010). Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: The influence of PCO2 gradients. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 298, R1648-R1658.
Faraci, F. M., Mayhan, W. G., & Heistad, D. D. (1987). Segmental vascular responses to acute hypertension in cerebrum and brain stem. American Journal of Physiology, 252, H738-H742.
Fierstra, J., Sobczyk, O., Battisti-Charbonney, A., Mandell, D. M., Poublanc, J., Crawley, A. P., & Fisher, J. A. (2013). Measuring cerebrovascular reactivity: What stimulus to use ? Journal of Physiology, 591, 5809-5821.
Fisher, J. A. (2016). The CO2 stimulus for cerebrovascular reactivity: Fixing inspired concentrations vs. targeting end-tidal partial pressures. Journal of Cerebral Blood Flow and Metabolism, 36, 1004-1011.
Fisher, J. A., Iscoe, S., & Duffin, J. (2016). Sequential gas delivery provides precise control of alveolar gas exchange. Respiratory Physiology & Neurobiology, 225, 60-69.
Giannoni, A., Emdin, M., Poletti, R., Bramanti, F., Prontera, C., Piepoli, M., & Passino, C. (2008). Clinical significance of chemosensitivity in chronic heart failure: Influence on neurohormonal derangement, Cheyne-Stokes respiration and arrhythmias. Clinical Science, 114, 489-497.
Hirshman, C. A., Mccullough, R. E., Weil J, V., & Hirshman, A. (1975). Normal values for hypoxic and hypercapnic ventilatory drives in man normal ventilatory values for hypoxic in man and hypercapnic drives. Journal of Applied Physiology, 38, 1095-1098.
Hoiland, R. L., Fisher, J. A., & Ainslie, P. N. (2019). Regulation of the cerebral circulation by arterial carbon dioxide. Comprehensive Physiology 9, 1101-1154.
Hoiland, R. L., Tymko, M. M., Bain, A. R., Wildfong, K. W., Monteleone, B., & Ainslie, P. N. (2016). Carbon dioxide mediated vasomotion of extra-cranial cerebral arteries in humans: A role for prostaglandins? Journal of Physiology, 594, 3463-3481.
Ito, S., Mardimae, A., Han, J., Duffin, J., Wells, G., Fedorko, L., & Fisher, J. A. (2008). Non-invasive prospective targeting of arterial PCO2 in subjects at rest. Journal of Physiology, 586, 3675-3682.
Jones, N. L., Robertson, D. G., Kane, J. W., & Grobertson, D. (1979). Difference between end-tidal and arterial PCO2 in exercise. Journal of Applied Physiology. Respiratory, Environmental and Exercise Physiology, 47, 954-960.
Kety, S. S., & Schmidt, C. F. (1948). The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. Journal of Clinical Investigation, 27, 484-492.
Lu, H., Liu, P., Yezhuvath, U., Cheng, Y., Marshall, O., & Ge, Y. (2014). MRI mapping of cerebrovascular reactivity via gas inhalation challenges. Journal of Visualized Experiments, 94, e52306.
Markus, H., & Cullinane, M. (2001). Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion. Brain, 124, 457-467.
Nattie, E., & Li, A. (2012). Central chemoreceptors: Locations and functions. Comprehensive Physiology, 2, 221-254.
Neubauer, J. A., Santiago T, V., Posner, M. A., & Edelman, N. H. (1985). Ventral medullary pH and ventilatory to hyperperfusion and hypoxia responses. Journal of Applied Physiology, 58, 1659-1668.
Neubauer, J. A., Strumpf, D. A., & Edelman, N. H. (1983). Regional medullary blood flow during isocapnic hyperpnea in anesthetized cats. Journal of Applied Physiology, 55, 447-452.
Nowak-Flück, D., Ainslie, P. N., Bain, A. R., Ahmed, A., Wildfong, K. W., Morris, L. E., & Fisher, JP. (2018). Effect of healthy aging on cerebral blood flow, CO2 reactivity, and neurovascular coupling during exercise. Journal of Applied Physiology, 125, 1917-1930.
Ogoh, S., Saito, S., Miyamoto, T., Bailey, T. G., Washio, T., Shibata, S., & Tamiya, K. (2019). Does respiratory drive modify the cerebral vascular response to changes in end-tidal carbon dioxide ? Experimental Physiology, 104, 1363-1370.
Peebles, K., Celi, L., McGrattan, K., Murrell, C., Thomas, K., & Ainslie, P. N. (2007). Human cerebrovascular and ventilatory CO2 reactivity to end-tidal, arterial and internal jugular vein PCO2. Journal of Physiology, 584, 347-357.
Peebles, K. C., Ball, O. G., MacRae, B. A., Horsman, H. M., & Tzeng, Y. C. (2012). Sympathetic regulation of the human cerebrovascular response to carbon dioxide. Journal of Applied Physiology, 113, 700-706.
Peltonen, G. L., Harrell, J. W., Aleckson, B. P., LaPlante, K. M., Crain, M. K., & Schrage, W. G. (2016). Cerebral blood flow regulation in women across menstrual phase: Differential contribution of cyclooxygenase to basal, hypoxic, and hypercapnic vascular tone. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311, R222-R231.
Peltonen, G. L., Harrell, J. W., Rousseau, C. L., Ernst, B. S., Marino, M. L., Crain, M. K., & Schrage, W. G. (2015). Cerebrovascular regulation in men and women: Stimulus-specific role of cyclooxygenase. Physiological Reports, 3, e12451.
Przybyłowski, T., Bangash, M-F., Reichmuth, K., Morgan, B. J., Skatrud, J. B., & Dempsey, J. A. (2003). Mechanisms of the cerebrovascular response to apnoea in humans. Journal of Physiology, 548, 323-332.
Read, D. J. C., & Leigh, J. (1967). Blood-brain tissue Pco2 relationships and ventilation during rebreathing. Journal of Applied Physiology, 23, 53-70.
Regan, R. E., Fisher, J. A., & Duffin, J. (2014). Factors affecting the determination of cerebrovascular reactivity. Brain and Behavior, 4, 775-788.
Robbins, P. A., Swanson, G. D., & Howson, M. G. (1982a). A prediction-correction scheme for forcing alveolar gases along certain times courses. Journal of Applied Physiology. Respiratory, Environmental and Exercise Physiology, 52, 1353-1357.
Robbins, P. A., Swanson, G. D., Micco, A. J., & Schubert, W. P. (1982b). A fast gas-mixing system for breath-to-breath respiratory control studies. Journal of Applied Physiology. Respiratory, Environmental and Exercise Physiology, 52, 1358-1362.
Smith, K. J., Wildfong, K. W., Hoiland, R. L., Harper, M., Lewis, N. C., Pool, A., & Ainslie, P. N. (2016). Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise. Journal of Applied Physiology, 120, 843-854.
Stark, R. D. (1968). Conductance or resistance? Nature, 217, 779.
Steinback, C. D., Breskovic, T., Frances, M., Dujic, Z., & Shoemaker, J. K. (2010). Ventilatory restraint of sympathetic activity during chemoreflex stress. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 299, 1407-1414.
Steinback, C. D., Salzer, D., Medeiros, P. J., Kowalchuk, J., & Shoemaker, J. K. (2009). Hypercapnic vs. hypoxic control of cardiovascular, cardiovagal, and sympathetic function. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 296, R402-R410.
Thomas, K. N., Lewis, N. C. S., Hill, B. G., & Ainslie, P. N. (2015). Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 309, R707-R720.
Tymko, M. M., Hoiland, R. L., Kuca, T., Boulet, L. M., Tremblay, J. C., Pinske, B. K., & Foster, G. E. (2016). Measuring the human ventilatory and cerebral blood flow response to CO2: A technical consideration for the end-tidal-to-arterial gas gradient. Journal of Applied Physiology, 120, 282-296.
Willie, C. K., Colino, F. L., Bailey, D. M., Tzeng, Y. C., Binsted, G., Jones, L. W., & Ainslie, P. N. (2011). Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. Journal of Neuroscience Methods, 196, 221-237.
Willie, C. K., Macleod, D. B., Shaw, A. D., Smith, K. J., Tzeng, Y. C., Eves, N. D., & Ainslie, P. N. (2012). Regional brain blood flow in man during acute changes in arterial blood gases. Journal of Physiology, 590, 3261-3275.
Willie, C. K., Tzeng, Y-C., Fisher, J. A., & Ainslie, P. N. (2014). Integrative regulation of human brain blood flow. Journal of Physiology, 592, 841-859.
Woodman, R. J., Playford, D. A., Watts, G. F., Cheetham, C., Reed, C., Taylor, R. R., & Green, D. (2001). Improved analysis of brachial artery ultrasound using a novel edge-detection software system. Journal of Applied Physiology, 91, 929-937.
Xie, A., Skatrud, J. B., Barczi, S. R., Reichmuth, K., Morgan, B. J., Mont, S., & Dempsey, J. A. (2009). Influence of cerebral blood flow on breathing stability. Journal of Applied Physiology, 106, 850-856.
Xie, A., Skatrud, J. B., Khayat, R., Dempsey, J. A., Morgan, B., & Russell, D. (2005). Cerebrovascular response to carbon dioxide in patients with congestive heart failure. American Journal of Respiratory and Critical Care Medicine, 172, 371-378.
Xie, A., Skatrud, J. B., Morgan, B., Chenuel, B., Khayat, R., Reichmuth, K., & Dempsey, J. A. (2006). Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. Journal of Physiology, 577, 319-329.