Norepinephrine, neurodevelopment and behavior.
Adrenergic receptors
Behavior
Locus coeruleus
Neurodevelopment
Norepinephrine
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
24
01
2020
revised:
14
02
2020
accepted:
16
02
2020
pubmed:
25
2
2020
medline:
26
1
2021
entrez:
25
2
2020
Statut:
ppublish
Résumé
Neurotransmitters play critical roles in the developing nervous system. Among the neurotransmitters, norepinephrine (NE) is in particular postulated to be an important regulator of brain development. NE is expressed during early stages of development and is known to regulate both the development of noradrenergic neurons and the development of target areas. NE participates in the shaping and the wiring of the nervous system during the critical periods of development, and perturbations in this process can alter the brain's developmental trajectory, which in turn can cause long-lasting and even permanent changes in the brain function and behavior later in life. Here we will briefly review evidence for the role of noradrenergic system in neurodevelopmental processes and will discuss about the potential disruptors of noradrenergic system during development and their behavioral consequences.
Identifiants
pubmed: 32092327
pii: S0197-0186(20)30097-8
doi: 10.1016/j.neuint.2020.104706
pii:
doi:
Substances chimiques
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104706Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have declared no conflict of interest.