Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Animals
Cell Cycle Proteins
/ physiology
Cell Line
Gene Expression Regulation
Humans
Mice
Microtubule-Associated Proteins
/ physiology
Mitogen-Activated Protein Kinases
/ metabolism
Muscle, Skeletal
/ metabolism
Muscular Atrophy
/ metabolism
Myoblasts
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
AKT signaling, casein kinase 1α
Atrophy
Fam83d
MAP kinase signaling
Skeletal muscle
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
17
11
2019
revised:
20
02
2020
accepted:
20
02
2020
pubmed:
25
2
2020
medline:
10
8
2021
entrez:
25
2
2020
Statut:
ppublish
Résumé
Skeletal muscle atrophy is a serious health condition that can arise due to aging, cancer, corticosteroid exposure, and denervation. Previous work comparing gene expression profiles in control and denervated muscle tissue revealed for the first time that Fam83d is expressed in skeletal muscle and is significantly induced in response to denervation. Quantitative PCR and Western blot analysis found that Fam83d is more highly expressed in proliferating myoblasts compared to differentiated myotubes. Characterization of the transcriptional regulation of Fam83d showed that ectopic expression of myogenic regulatory factors inhibits Fam83d reporter gene activity. To assess where Fam83d is localized in the cell, Fam83d was fused with green fluorescent protein, expressed in C
Identifiants
pubmed: 32092437
pii: S0898-6568(20)30053-X
doi: 10.1016/j.cellsig.2020.109576
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
FAM83D protein, human
0
Microtubule-Associated Proteins
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109576Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interest.