Chemical structures and cytotoxic activities of the constituents isolated from Hibiscus tiliaceus.
ECD prediction
Hibiscus tiliaceus
Hibiscusterpene
Time-lapse cell imaging
X-ray crystallography
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
10
12
2019
revised:
16
02
2020
accepted:
19
02
2020
pubmed:
25
2
2020
medline:
19
12
2020
entrez:
25
2
2020
Statut:
ppublish
Résumé
Five new cadinene-type sesquiterpenes, hibiscusterpenes I-V (1-5), and six known compounds (6-11) have been isolated from the methanol extract of the stems and the twigs of Hibiscus tiliaceus. The structures of the new compounds were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry of hibiscusterpene I (1) was determined using X-ray crystallography. For hibiscusterpene III (3), the absolute configuration was established upon comparison of the experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, hibiscone C (7) and syriacusin A (11) showed cytotoxic activity in HeLa cells. In addition, their cell death-inducing activity was observed using time-lapse cell imaging.
Identifiants
pubmed: 32092530
pii: S0367-326X(20)30106-4
doi: 10.1016/j.fitote.2020.104524
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Terpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104524Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.