Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells.
calcium
insulin
kaempferol
mitochondria
mitoxantrone
polyphenols
β-cell
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Feb 2020
19 Feb 2020
Historique:
received:
27
01
2020
accepted:
14
02
2020
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Pancreatic β-cells secrete insulin to lower blood glucose, following a meal. Maintenance of β-cell function is essential to preventing type 2 diabetes. In pancreatic β-cells, mitochondrial matrix calcium is an activating signal for insulin secretion. Recently, the molecular identity of the mitochondrial calcium uniporter (MCU), the transporter that mediates mitochondrial calcium uptake, was revealed. Its role in pancreatic β-cell signal transduction modulation was clarified, opening new perspectives for intervention. Here, we investigated the effects of a mitochondrial Ca
Identifiants
pubmed: 32093050
pii: nu12020538
doi: 10.3390/nu12020538
pmc: PMC7071504
pii:
doi:
Substances chimiques
Calcium Channels
0
Kaempferols
0
mitochondrial calcium uniporter
0
kaempferol
731P2LE49E
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors are employees of Nestlé Research, which is part of the Société des Produits Nestlé SA.
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