NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis.
NADPH oxidase
atherosclerosis
intima-media thickness
oxidative stress
telomere length
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Feb 2020
20 Feb 2020
Historique:
received:
30
12
2019
revised:
10
02
2020
accepted:
18
02
2020
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Telomere shortening and oxidative stress are involved in the pathogenesis of atherosclerosis. Different studies have shown that phagocytic NADPH oxidase is associated with this disease. This study aimed to investigate the association between phagocytic NADPH oxidase and telomere shortening in human atherosclerosis. To assess this potential association, telomere length and phagocytic NADPH oxidase activity were determined by PCR and chemiluminescence, respectively, in a population of asymptomatic subjects free of overt clinical atherosclerosis. We also measured serum 8-hydroxy-2-deoxyguanosine (8-OHdG) levels (an index of oxidative stress) and carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis. After adjusting them for age and sex, telomere length inversely correlated (
Identifiants
pubmed: 32093292
pii: ijms21041434
doi: 10.3390/ijms21041434
pmc: PMC7073034
pii:
doi:
Substances chimiques
Biomarkers
0
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
NADPH Oxidases
EC 1.6.3.-
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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