Seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome.
Autoimmune diseases
Clinical trials
Epidemiology
Outcome measures
Patient-reported outcomes (PROs)
Primary Sjögren’s syndrome
Seasonality
Seasons and rheumatic diseases
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
24 02 2020
24 02 2020
Historique:
received:
06
07
2019
accepted:
06
02
2020
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
25
11
2020
Statut:
epublish
Résumé
To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome (pSS). Data (date; visual analogue scales (VAS) for pain, fatigue and dryness) were extracted from three randomised placebo-controlled trials (RCTs) evaluating infliximab (TRIPSS; n = 103 patients), hydroxychloroquine (JOQUER; n = 120 patients) and rituximab (TEARS; n = 120 patients) and from the 5-year follow-up of the ASSESS prospective cohort (n = 395 patients). Data were analysed at each visit for each patient, according to the day, the month of the year and the season. Linear mixed models were used to take into account the repeated structure of the data and to analyse a potential cyclic effect. A total of 744, 584, 848 and 682 pain, fatigue and dryness VASs were collected on 632 subjects in spring, summer, fall and winter, respectively. No significant difference was observed in pain, fatigue and dryness, according to the month of the year or the season (all p values > 0.05). In pSS, seasonality does not affect patient-reported outcomes (PROs) on fatigue, pain and dryness.
Sections du résumé
BACKGROUND
To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome (pSS).
METHODS
Data (date; visual analogue scales (VAS) for pain, fatigue and dryness) were extracted from three randomised placebo-controlled trials (RCTs) evaluating infliximab (TRIPSS; n = 103 patients), hydroxychloroquine (JOQUER; n = 120 patients) and rituximab (TEARS; n = 120 patients) and from the 5-year follow-up of the ASSESS prospective cohort (n = 395 patients). Data were analysed at each visit for each patient, according to the day, the month of the year and the season. Linear mixed models were used to take into account the repeated structure of the data and to analyse a potential cyclic effect.
RESULTS
A total of 744, 584, 848 and 682 pain, fatigue and dryness VASs were collected on 632 subjects in spring, summer, fall and winter, respectively. No significant difference was observed in pain, fatigue and dryness, according to the month of the year or the season (all p values > 0.05).
CONCLUSION
In pSS, seasonality does not affect patient-reported outcomes (PROs) on fatigue, pain and dryness.
Identifiants
pubmed: 32093783
doi: 10.1186/s13075-020-2118-1
pii: 10.1186/s13075-020-2118-1
pmc: PMC7041128
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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