In a Phase 1a escalating clinical trial, autologous mesenchymal stem cell infusion for renovascular disease increases blood flow and the glomerular filtration rate while reducing inflammatory biomarkers and blood pressure.
blood flow
blood pressure
clinical trial
kidney oxygenation
renal artery stenosis
stem cells
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
11
06
2019
revised:
14
11
2019
accepted:
22
11
2019
pubmed:
26
2
2020
medline:
22
6
2021
entrez:
26
2
2020
Statut:
ppublish
Résumé
Atherosclerotic renovascular disease (ARVD) reduces tissue perfusion and eventually leads to loss of kidney function with limited therapeutic options. Here we describe results of Phase 1a escalating dose clinical trial of autologous mesenchymal stem cell infusion for ARVD. Thirty-nine patients with ARVD were studied on two occasions separated by three months. Autologous adipose-derived mesenchymal stem cells were infused through the renal artery in 21 patients at three different dose levels (1, 2.5 and 5.0 × 10
Identifiants
pubmed: 32093917
pii: S0085-2538(19)31218-9
doi: 10.1016/j.kint.2019.11.022
pmc: PMC7284953
mid: NIHMS1546578
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-804Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK109134
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK118120
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100081
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL085307
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK073608
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL098967
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024150
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102325
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Références
Acta Physiol (Oxf). 2019 Jul;226(3):e13267
pubmed: 30803138
Hypertension. 2018 Nov;72(5):1180-1188
pubmed: 30354805
Stem Cell Res Ther. 2015 Mar 24;6:44
pubmed: 25888925
Circ Cardiovasc Interv. 2013 Aug;6(4):428-35
pubmed: 23899868
Kidney Int. 1996 Mar;49(3):846-54
pubmed: 8648929
Kidney Int. 2012 Oct;82(7):748-58
pubmed: 22695328
Acad Radiol. 2019 Nov;26(11):1488-1494
pubmed: 30655055
Cytotherapy. 2012 Feb;14(2):162-72
pubmed: 21954833
Am J Hypertens. 2010 Nov;23(11):1159-69
pubmed: 20864945
Hypertension. 2010 Apr;55(4):961-6
pubmed: 20194303
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17384-9
pubmed: 21960443
Cell. 2003 Mar 7;112(5):645-57
pubmed: 12628185
Nephrol Dial Transplant. 2015 Mar;30(3):366-75
pubmed: 24723543
Radiology. 2013 Sep;268(3):770-8
pubmed: 23788716
Radiology. 2015 Aug;276(2):490-8
pubmed: 25848903
J Intern Med. 2007 Nov;262(5):509-25
pubmed: 17949362
N Engl J Med. 2009 Nov 12;361(20):1953-62
pubmed: 19907042
Kidney Int. 2019 Apr;95(4):948-957
pubmed: 30904069
Stem Cell Res Ther. 2016 Sep 09;7(1):128
pubmed: 27612459
N Engl J Med. 2014 Jan 2;370(1):13-22
pubmed: 24245566
Eur Heart J. 2013 Feb;34(7):540-548a
pubmed: 22771675
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Ann Intern Med. 2009 Jun 16;150(12):840-8, W150-1
pubmed: 19414832
Mol Biol Rep. 2009 Jul;36(6):1323-9
pubmed: 18649012
Kidney Int Suppl. 2000 Apr;75:S22-6
pubmed: 10828757
Int J Mol Med. 2017 Apr;39(4):918-926
pubmed: 28259958
N Engl J Med. 2011 Feb 17;364(7):656-65
pubmed: 21323543
J Cardiovasc Comput Tomogr. 2018 Mar - Apr;12(2):149-152
pubmed: 29339048
Circulation. 1999 Nov 9;100(19 Suppl):II301-8
pubmed: 10567320
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18154-9
pubmed: 17114296
Nat Med. 2009 Jan;15(1):42-9
pubmed: 19098906
Stem Cells. 2012 May;30(5):1030-41
pubmed: 22290832
N Engl J Med. 2001 Feb 8;344(6):431-42
pubmed: 11172181
Immunol Lett. 2008 Jan 15;115(1):50-8
pubmed: 18022251
Kidney Int. 2018 Apr;93(4):814-825
pubmed: 29132705
Am J Physiol Renal Physiol. 2008 Nov;295(5):F1259-70
pubmed: 18550645
J Am Soc Nephrol. 2018 Feb;29(2):362-375
pubmed: 29191959
Nature. 1992 Oct 29;359(6398):843-5
pubmed: 1279431
Ren Fail. 2009;31(6):492-502
pubmed: 19839827
Stem Cells. 2009 Dec;27(12):3063-73
pubmed: 19750536
J Am Soc Nephrol. 2017 Sep;28(9):2777-2785
pubmed: 28461553
Cell Transplant. 2011;20(6):797-811
pubmed: 21092406
Stem Cells. 2016 Jul;34(7):1909-21
pubmed: 27015881
Clin J Am Soc Nephrol. 2016 Mar 7;11(3):458-69
pubmed: 26787779