Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
22
11
2019
revised:
28
01
2020
accepted:
19
02
2020
pubmed:
26
2
2020
medline:
27
10
2020
entrez:
26
2
2020
Statut:
ppublish
Résumé
Targeting epigenetic regulators, such as histone-modifying enzymes, provides novel strategies for cancer therapy. The GCN5 lysine acetyltransferase (KAT) functions together with MYC both during normal development and in oncogenesis. As transcription factors, MYC family members are difficult to target with small-molecule inhibitors, but the acetyltransferase domain and the bromodomain in GCN5 might provide alternative targets for disruption of MYC-driven functions. GCN5 is part of two distinct multiprotein histone-modifying complexes, SAGA and ATAC. This review summarizes key findings on the roles of SAGA and ATAC in embryo development and in cancer to better understand the functional relationships of these complexes with MYC family members, as well as their future potential as therapeutic targets.
Identifiants
pubmed: 32094302
pii: 0008-5472.CAN-19-3652
doi: 10.1158/0008-5472.CAN-19-3652
pmc: PMC7231639
mid: NIHMS1567438
doi:
Substances chimiques
Proto-Oncogene Proteins c-myc
0
Transcription Factors
0
p300-CBP Transcription Factors
EC 2.3.1.48
p300-CBP-associated factor
EC 2.3.1.48
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1905-1911Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM067718
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094400
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131678
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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