Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
06
03
2019
accepted:
30
01
2020
revised:
31
12
2019
pubmed:
26
2
2020
medline:
3
2
2022
entrez:
26
2
2020
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [
Identifiants
pubmed: 32094584
doi: 10.1038/s41380-020-0674-z
pii: 10.1038/s41380-020-0674-z
pmc: PMC7484380
mid: NIHMS1615402
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5940-5954Subventions
Organisme : NICHD NIH HHS
ID : K01 HD074651
Pays : United States
Organisme : RRD VA
ID : I01 RX002333
Pays : United States
Organisme : RRD VA
ID : I21 RX002876
Pays : United States
Organisme : RRD VA
ID : I01 RX000996
Pays : United States
Organisme : RRD VA
ID : I01 RX000684
Pays : United States
Organisme : RRD VA
ID : I21 RX002069
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066514
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS086625
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH080328
Pays : United States
Organisme : BLRD VA
ID : I01 BX004067
Pays : United States
Organisme : RRD VA
ID : I01 RX002660
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107555
Pays : United States
Organisme : RRD VA
ID : I01 RX003087
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020. The Author(s).
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