Effects of a gintonin-enriched fraction on hair growth: an
Ginseng
Gintonin-enriched fraction
Hair growth
Human hair follicle dermal papilla cells
Mouse
Journal
Journal of ginseng research
ISSN: 1226-8453
Titre abrégé: J Ginseng Res
Pays: Korea (South)
ID NLM: 100890690
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
11
03
2019
revised:
18
05
2019
accepted:
31
05
2019
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
26
2
2020
Statut:
ppublish
Résumé
Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and mutations in the LPA6 receptor impair normal human hair growth. Currently, human hair loss and alopecia are concerning issues that affect peoples' social and day-to-day lives. We investigated the Human hair follicle dermal papilla cells (HFDPCs) and six-week-old male C57BL/6 mice were used. The mice were divided into the four groups: control, 1% minoxidil, 0.75% GEF, and 1.5% GEF. The dorsal hair was removed to synchronize the telogen phase. Each group was treated topically, once a day, for 15 days. We analyzed hair growth activity and histological changes. GEF induced transient [Ca Topical application of GEF promotes mouse hair growth through HFDPC proliferation. GEF could be one of the main components of ginseng that promote hair growth and could be used to treat human alopecia.
Sections du résumé
BACKGROUND
BACKGROUND
Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and mutations in the LPA6 receptor impair normal human hair growth. Currently, human hair loss and alopecia are concerning issues that affect peoples' social and day-to-day lives.
OBJECTIVE
OBJECTIVE
We investigated the
METHODS
METHODS
Human hair follicle dermal papilla cells (HFDPCs) and six-week-old male C57BL/6 mice were used. The mice were divided into the four groups: control, 1% minoxidil, 0.75% GEF, and 1.5% GEF. The dorsal hair was removed to synchronize the telogen phase. Each group was treated topically, once a day, for 15 days. We analyzed hair growth activity and histological changes.
RESULTS
RESULTS
GEF induced transient [Ca
CONCLUSION
CONCLUSIONS
Topical application of GEF promotes mouse hair growth through HFDPC proliferation. GEF could be one of the main components of ginseng that promote hair growth and could be used to treat human alopecia.
Identifiants
pubmed: 32095099
doi: 10.1016/j.jgr.2019.05.013
pii: S1226-8453(19)30075-2
pmc: PMC7033365
doi:
Types de publication
Journal Article
Langues
eng
Pagination
168-177Informations de copyright
© 2019 The Korean Society of Ginseng. Publishing services by Elsevier B.V.
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