Anellovirus Dynamics Are Associated With Primary Graft Dysfunction in Lung Transplantation.
Journal
Transplantation direct
ISSN: 2373-8731
Titre abrégé: Transplant Direct
Pays: United States
ID NLM: 101651609
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
25
09
2019
revised:
21
11
2019
accepted:
23
11
2019
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
26
2
2020
Statut:
epublish
Résumé
Primary graft dysfunction (PGD) is the leading cause of early death in lung transplant. Anelloviruses are small circular DNA viruses that have been noted to be present at elevated levels in immunosuppressed patients. They have been associated with both short- and long-term outcomes in lung transplant, and we hypothesized that anellovirus dynamics might be associated with the development of PGD. We analyzed alphatorquevirus (ie, an anellovirus genus) levels in whole blood samples from 64 adult lung transplant recipients. Patients with a relatively rapid rise in alphatorquevirus levels in the week following transplant were less likely to develop higher-grade PGD over the first 3 days following transplant ( This study is the first to establish an association between the development of PGD and a component of the blood virome. While it is not known whether anelloviruses directly affect outcomes in lung transplant, they may serve as a biomarker of immune status in lung transplant recipients.
Identifiants
pubmed: 32095507
doi: 10.1097/TXD.0000000000000969
pmc: PMC7004632
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e521Subventions
Organisme : NHLBI NIH HHS
ID : R33 HL137079
Pays : United States
Organisme : NHLBI NIH HHS
ID : R61 HL137079
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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