A step and shoot intensity modulated technique for total body irradiation.
Bone marrow transplant
IMRT
Imaging
In-vivo dosimetry
Total body irradiation
Journal
Technical innovations & patient support in radiation oncology
ISSN: 2405-6324
Titre abrégé: Tech Innov Patient Support Radiat Oncol
Pays: England
ID NLM: 101762366
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
13
03
2019
revised:
14
05
2019
accepted:
24
05
2019
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
26
2
2020
Statut:
epublish
Résumé
Total body irradiation (TBI) is a part of the conditioning regimen for bone marrow transplant.At the Royal Marsden (Sutton, UK) and Rigshospitalet (Copenhagen, Denmark), we introduced a step and shoot IMRT (SS IMRT) technique for TBI. This technique requires no equipment other than that used to deliver other external beam radiation. In this paper, we describe this technique and report on data from the two clinics. The patients were positioned supine, supported by vacuum bag(s). The entire body of the patients were CT scanned with 5 mm slices. Multiple multi-leaf collimator (MLC) defined fields were used.In-vivo dosimetry was performed at the Royal Marsden for 113 patients.Calculated doses for 18 adult and 4 paediatric patients from Rigshospitalet were extracted. The in-vivo data from the Royal Marsden showed that the mean TLD measured dose difference was -1.9% with a standard deviation of 4.5%.SS IMRT plans for 22 patients from Rigshospitalet resulted in mean doses to the brain, lungs and kidneys all within the range of 11.1-11.8 Gy, while the V(12 Gy) was below 5% for the brain, 2% for the lungs and 0% for the kidneys. SS IMRT is feasible for TBI and can deliver targeted doses to the organs at risk.
Identifiants
pubmed: 32095540
doi: 10.1016/j.tipsro.2019.05.002
pii: S2405-6324(19)30004-6
pmc: PMC7033804
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-7Informations de copyright
© 2019 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy & Oncology.
Déclaration de conflit d'intérêts
None.
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