Post-Transplantation Diabetes Mellitus.
Calcineurin inhibitors
Diabetes mellitus
Graft failure
Macrovascular
Microvascular
Mortality
Post-transplantation
Rejection
Steroids
mTOR inhibitors
Journal
Diabetes therapy : research, treatment and education of diabetes and related disorders
ISSN: 1869-6953
Titre abrégé: Diabetes Ther
Pays: United States
ID NLM: 101539025
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
03
01
2020
pubmed:
26
2
2020
medline:
26
2
2020
entrez:
26
2
2020
Statut:
ppublish
Résumé
Solid organ transplantation (SOT) is an established therapeutic option for chronic disease resulting from end-stage organ dysfunction. Long-term use of immunosuppression is associated with post-transplantation diabetes mellitus (PTDM), placing patients at increased risk of infections, cardiovascular disease and mortality. The incidence rates for PTDM have varied from 10 to 40% between different studies. Diagnostic criteria have evolved over the years, as a greater understating of PTDM has been reached. There are differences in pathophysiology and clinical course of type 2 diabetes and PTDM. Hence, managing this condition can be a challenge for a diabetes physician, as there are several factors to consider when tailoring therapy for post-transplant patients to achieve better glycaemic as well as long-term transplant outcomes. This article is a detailed review of PTDM, examining the pathogenesis, diagnostic criteria and management in light of the current evidence. The therapeutic options are discussed in the context of their safety and potential drug-drug interactions with immunosuppressive agents.
Identifiants
pubmed: 32095994
doi: 10.1007/s13300-020-00790-5
pii: 10.1007/s13300-020-00790-5
pmc: PMC7136383
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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