Patellofemoral alignment and geometry and early signs of osteoarthritis are associated in patellofemoral pain population.
alignment
cartilage
geometry
magnetic resonance imaging
osteoarthritis
patellofemoral joint
patellofemoral pain
perfusion
structural abnormalities
Journal
Scandinavian journal of medicine & science in sports
ISSN: 1600-0838
Titre abrégé: Scand J Med Sci Sports
Pays: Denmark
ID NLM: 9111504
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
02
08
2019
revised:
03
02
2020
accepted:
06
02
2020
pubmed:
26
2
2020
medline:
31
7
2020
entrez:
26
2
2020
Statut:
ppublish
Résumé
Patellofemoral pain (PFP) patients show increased prevalence of patellar malalignment. Structural and alignment abnormalities of the patellofemoral joint (PFJ) may play a role in development of PFP and patellofemoral osteoarthritis (PFOA). Evaluating associations of patellofemoral alignment and femoral geometry with bony and cartilaginous abnormalities in PFP patients and healthy control subjects. Data from a case-control study were used (64 PFP subjects, 70 control subjects, 57% female, age 23.2 (6.4)). Alignment and femoral geometry measures in the PFJ were determined using MRI. Structural abnormalities in the PFJ associated with OA (bone marrow lesions, osteophytes, minor cartilage defects and Hoffa-synovitis), quantified cartilage composition (T1ρ relaxation times) in the PFJ and perfusion within the patellar bone were examined using different MRI techniques. Associations were analyzed using regression analyses, adjusted for potential confounders. Lateral patellar tilt was negatively associated with presence of osteophytes on both patella (OR 0.91; 95% CI 0.84 to 0.98), anterior femur (OR 0.92; 95% CI 0.84 to 0.99) and minor cartilage defects on patella (OR 0.91; 95% CI 0.84 to 0.99). Patella alta was positively associated with the presence of bone marrow lesions in the patella and minor cartilage defects (OR 48.33; 95% CI 4.27 to 547.30 and OR 17.51; 95% CI 1.17 to 262.57, respectively). Patella alta and medial patellar translation were positively associated with T1ρ relaxation times within trochlear cartilage (β 5.2; 95% CI 0.77 to 9.58, and 0.36; 95% CI 0.08 to 0.64, respectively). None of the alignment and geometry measures were associated with bone perfusion. Our study implies that associations between patellofemoral alignment and geometry and structural joint abnormalities linked to OA are already present in both PFP patients and healthy control subjects.
Sections du résumé
BACKGROUND
BACKGROUND
Patellofemoral pain (PFP) patients show increased prevalence of patellar malalignment. Structural and alignment abnormalities of the patellofemoral joint (PFJ) may play a role in development of PFP and patellofemoral osteoarthritis (PFOA).
OBJECTIVES
OBJECTIVE
Evaluating associations of patellofemoral alignment and femoral geometry with bony and cartilaginous abnormalities in PFP patients and healthy control subjects.
METHODS
METHODS
Data from a case-control study were used (64 PFP subjects, 70 control subjects, 57% female, age 23.2 (6.4)). Alignment and femoral geometry measures in the PFJ were determined using MRI. Structural abnormalities in the PFJ associated with OA (bone marrow lesions, osteophytes, minor cartilage defects and Hoffa-synovitis), quantified cartilage composition (T1ρ relaxation times) in the PFJ and perfusion within the patellar bone were examined using different MRI techniques. Associations were analyzed using regression analyses, adjusted for potential confounders.
RESULTS
RESULTS
Lateral patellar tilt was negatively associated with presence of osteophytes on both patella (OR 0.91; 95% CI 0.84 to 0.98), anterior femur (OR 0.92; 95% CI 0.84 to 0.99) and minor cartilage defects on patella (OR 0.91; 95% CI 0.84 to 0.99). Patella alta was positively associated with the presence of bone marrow lesions in the patella and minor cartilage defects (OR 48.33; 95% CI 4.27 to 547.30 and OR 17.51; 95% CI 1.17 to 262.57, respectively). Patella alta and medial patellar translation were positively associated with T1ρ relaxation times within trochlear cartilage (β 5.2; 95% CI 0.77 to 9.58, and 0.36; 95% CI 0.08 to 0.64, respectively). None of the alignment and geometry measures were associated with bone perfusion.
CONCLUSION
CONCLUSIONS
Our study implies that associations between patellofemoral alignment and geometry and structural joint abnormalities linked to OA are already present in both PFP patients and healthy control subjects.
Identifiants
pubmed: 32096249
doi: 10.1111/sms.13641
pmc: PMC7187437
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
885-893Subventions
Organisme : Stichting Anna Fonds | NOREF
Organisme : Dutch Arthritis Foundation
Organisme : Erasmus University Rotterdam
Informations de copyright
© 2020 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
Références
Arthritis Care Res (Hoboken). 2017 Jul;69(7):959-965
pubmed: 27696763
Clin Orthop Relat Res. 2010 Jan;468(1):266-75
pubmed: 19430854
Aust J Physiother. 1986;32(4):215-23
pubmed: 25025219
Br J Sports Med. 2016 Jul;50(14):881-6
pubmed: 26463119
Sports Med. 1999 Oct;28(4):245-62
pubmed: 10565551
Br J Sports Med. 2014 Mar;48(6):417-24
pubmed: 24311602
Arthritis Care Res (Hoboken). 2016 Oct;68(10):1453-70
pubmed: 26814979
Skeletal Radiol. 2011 Apr;40(4):375-87
pubmed: 20217407
Am J Sports Med. 2017 Apr;45(5):1102-1109
pubmed: 28029800
Osteoarthritis Cartilage. 2016 Dec;24(12):2055-2060
pubmed: 27432215
BMJ. 2006 May 6;332(7549):1080
pubmed: 16675816
Ann Rheum Dis. 2011 Sep;70(9):1599-604
pubmed: 21613308
J Orthop Sports Phys Ther. 2012 Feb;42(2):81-94
pubmed: 22031622
Am J Sports Med. 2016 Sep;44(9):2339-46
pubmed: 27206691
J Pediatr Orthop. 1998 Jan-Feb;18(1):118-22
pubmed: 9449112
J Bone Joint Surg Am. 1999 Mar;81(3):355-63
pubmed: 10199273
J Orthop Res. 2013 Mar;31(3):448-57
pubmed: 23165335
Br J Sports Med. 2017 Dec;51(24):1713-1723
pubmed: 29109118
Pain Med. 2018 Jan 1;19(1):184-192
pubmed: 28387861
J Orthop Res. 2010 Jul;28(7):865-72
pubmed: 20108348
Cochrane Database Syst Rev. 2015 Jan 20;1:CD010387
pubmed: 25603546
Scand J Med Sci Sports. 2020 May;30(5):885-893
pubmed: 32096249
Best Pract Res Clin Rheumatol. 2014 Feb;28(1):73-91
pubmed: 24792946
Cartilage. 2013 Oct 1;4(4):286-294
pubmed: 25067995
J Orthop Sports Phys Ther. 2012 Dec;42(12):1017-24
pubmed: 22960572
Arthritis Care Res (Hoboken). 2014 Aug;66(8):1129-41
pubmed: 24578345
Arthritis Res Ther. 2016 Jan 26;18:31
pubmed: 26817452
Am J Sports Med. 2013 Aug;41(8):1813-8
pubmed: 23845401
Arthritis Care Res (Hoboken). 2010 Sep;62(9):1258-65
pubmed: 20506169
Osteoarthritis Cartilage. 2011 Mar;19(3):287-94
pubmed: 21172445
Eur J Radiol. 2013 Nov;82(11):1946-52
pubmed: 23769189
Radiology. 1992 Dec;185(3):859-63
pubmed: 1438776
Scand J Med Sci Sports. 2016 May;26(5):572-8
pubmed: 25996828
J Orthop Res. 2012 Jan;30(1):1-8
pubmed: 21710542
Iowa Orthop J. 2017;37:101-108
pubmed: 28852343
Bone Joint Res. 2018 Oct 3;7(9):541-547
pubmed: 30294426
Am J Sports Med. 2016 May;44(5):1172-8
pubmed: 26951075
J Magn Reson Imaging. 2018 Mar;47(3):848-858
pubmed: 28707311
Osteoarthritis Cartilage. 2016 Feb;24(2):224-36
pubmed: 26471209
Arthritis Care Res (Hoboken). 2019 Aug;71(8):1068-1073
pubmed: 30133185
Br J Sports Med. 2002 Apr;36(2):95-101
pubmed: 11916889
Osteoarthritis Cartilage. 2007 Oct;15(10):1120-7
pubmed: 17502158
Arthritis Res Ther. 2012 Mar 14;14(2):R63
pubmed: 22417687
J Bone Joint Surg Br. 2009 Mar;91(3):344-50
pubmed: 19258610
Arthritis Rheum. 2004 Jul;50(7):2184-90
pubmed: 15248216
J Magn Reson Imaging. 2018 Nov;48(5):1344-1350
pubmed: 29734499
Br J Sports Med. 2014 Mar;48(6):409-10
pubmed: 24569144
Br J Sports Med. 2012 Jun;46(8):570-7
pubmed: 21402565