Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation.

Adult Germline Stem Cells / cytology Animals Cell Differentiation Humans Male Spermatogenesis
metabolism mitochondria spermatogenesis spermatogonial stem cells

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
24 02 2020
Historique:
received: 04 11 2019
revised: 27 11 2019
accepted: 13 01 2020
entrez: 26 2 2020
pubmed: 26 2 2020
medline: 5 8 2020
Statut: ppublish

Résumé

Male fertility is driven by spermatogonial stem cells (SSCs) that self-renew while also giving rise to differentiating spermatogonia. Spermatogonial transitions are accompanied by a shift in gene expression, however, whether equivalent changes in metabolism occur remains unexplored. In this review, we mined recently published scRNA-seq databases from mouse and human testes to compare expression profiles of spermatogonial subsets, focusing on metabolism. Comparisons revealed a conserved upregulation of genes involved in mitochondrial function, biogenesis, and oxidative phosphorylation in differentiating spermatogonia, while gene expression in SSCs reflected a glycolytic cell. Here, we also discuss the relationship between metabolism and the external microenvironment within which spermatogonia reside.

Identifiants

DOI: 10.1016/j.devcel.2020.01.014 PMID: 32097651
pubmed: 32097651
pii: S1534-5807(20)30015-0
doi: 10.1016/j.devcel.2020.01.014
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

399-411

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Tessa Lord (T)

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, the University of Newcastle, Callaghan, Newcastle, NSW 2300, Australia; Hunter Medical Research Institute, Pregnancy and Reproduction Program, New Lambton Heights, Newcastle, NSW 2305, Australia. Electronic address: tessa.lord@newcastle.edu.au.

Brett Nixon (B)

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, the University of Newcastle, Callaghan, Newcastle, NSW 2300, Australia; Hunter Medical Research Institute, Pregnancy and Reproduction Program, New Lambton Heights, Newcastle, NSW 2305, Australia.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules souches › Cellules souches adultes › Cellules souches germinales adultes › Metabolic Changes Accompanying Spermatogonial...
questionsmedicales.fr › Eucaryotes › Animaux › Metabolic Changes Accompanying Spermatogonial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Metabolic Changes Accompanying Spermatogonial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic Changes Accompanying Spermatogonial...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Gamétogenèse › Spermatogenèse › Metabolic Changes Accompanying Spermatogonial...