Disinhibition of sensory cortex in patients with amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis
GABA
High frequency oscillations
Hyperexcitability
Sensory cortex
Somatosensory evoked potentials
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
23 03 2020
23 03 2020
Historique:
received:
08
10
2019
revised:
05
02
2020
accepted:
21
02
2020
pubmed:
26
2
2020
medline:
20
4
2021
entrez:
26
2
2020
Statut:
ppublish
Résumé
In patients with amyotrophic lateral sclerosis (ALS) a motor cortical hyperexcitability has been reported in transcranial magnetic stimulation studies, but little is known about the neuronal excitability in other cortical areas. The aim of the present study was the functional evaluation of the sensory cortex in subjects with ALS by assessing the high-frequency somatosensory evoked potentials (HF-SEP). No significant HF-SEP abnormalities were observed in ALS patients with disease duration of <2 years, while the patients with a disease duration of>2 years we found a large amplitude reduction of post-synaptic HF-SEP burst. Since post-synaptic burst of HF-SEP is thought to reflect the activity of cortical inhibitory interneurons, our findings provide further evidence that disinhibition is a primary characteristic of ALS that also involves the somatosensory cortex.
Identifiants
pubmed: 32097703
pii: S0304-3940(20)30130-0
doi: 10.1016/j.neulet.2020.134860
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
134860Subventions
Organisme : Austrian Science Fund FWF
ID : W 1233
Pays : Austria
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors report no conflict of interest.