Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376.

Animals Antiviral Agents / chemistry Catalytic Domain Chlorocebus aethiops Crystallography, X-Ray Models, Molecular Peptide Hydrolases / chemistry Porcine epidemic diarrhea virus / drug effects Protease Inhibitors / chemistry Pyrrolidines / chemistry Substrate Specificity Sulfonic Acids Transmissible gastroenteritis virus / enzymology Vero Cells Virus Replication / drug effects
PEDV 3CLpro complex coronavirus crystal structure inhibitor

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
21 02 2020
Historique:
received: 23 12 2019
revised: 26 01 2020
accepted: 31 01 2020
entrez: 27 2 2020
pubmed: 27 2 2020
medline: 24 3 2020
Statut: epublish

Résumé

Porcine epidemic diarrhea virus (PEDV), being highly virulent and contagious in piglets, has caused significant damage to the pork industries of many countries worldwide. There are no commercial drugs targeting coronaviruses (CoVs), and few studies on anti-PEDV inhibitors. The coronavirus 3C-like protease (3CL

Identifiants

DOI: 10.3390/v12020240 PMID: 32098094 PMC: PMC7077318
pubmed: 32098094
pii: v12020240
doi: 10.3390/v12020240
pmc: PMC7077318
pii:
doi:

Substances chimiques

Antiviral Agents 0
Protease Inhibitors 0
Pyrrolidines 0
Sulfonic Acids 0
Peptide Hydrolases EC 3.4.-
GC376 H1NMJ5XDG5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Key R&D Plan of China
ID : 2018YFD0500100
Pays : International
Organisme : National Natural Science Foundation of China
ID : 31873020
Pays : International
Organisme : the Natural Science Foundation of Hubei Province of China
ID : 2016CFA069
Pays : International

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Auteurs

Gang Ye (G)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Xiaowei Wang (X)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Xiaohan Tong (X)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Yuejun Shi (Y)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Zhen F Fu (ZF)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Guiqing Peng (G)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Alphacoronavirus › Virus de la diarrhée porcine épidémique › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Alphacoronavirus › Alphacoronavirus-1 › Virus de la gastroentérite transmissible › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Structural Basis for Inhibiting Porcine...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Structural Basis for Inhibiting Porcine...