Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis.
Galectin 3
apoptosis
chondrocyte
mechanical stress
osteoarthritis
primary cilium
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Feb 2020
22 Feb 2020
Historique:
received:
21
12
2019
revised:
24
12
2019
accepted:
20
02
2020
entrez:
27
2
2020
pubmed:
27
2
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Mechanical overload and aging are the main risk factors of osteoarthritis (OA). Galectin 3 (GAL3) is important in the formation of primary cilia, organelles that are able to sense mechanical stress. The objectives were to evaluate the role of GAL3 in chondrocyte primary cilium formation and in OA in mice. Chondrocyte primary cilium was detected in vitro by confocal microscopy. OA was induced by aging and partial meniscectomy of wild-type (WT) and
Identifiants
pubmed: 32098291
pii: ijms21041486
doi: 10.3390/ijms21041486
pmc: PMC7073077
pii:
doi:
Substances chimiques
Galectin 3
0
Caspase 3
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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