Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium.
Animals
Epithelial Cells
/ metabolism
Epithelium
/ metabolism
Estradiol
/ metabolism
Estrogen Receptor alpha
/ biosynthesis
Female
Gene Expression Profiling
Gene Expression Regulation
Lipoylation
/ physiology
Mammary Glands, Animal
/ embryology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Paracrine Communication
/ physiology
Signal Transduction
ECM
Estrogen receptor alpha
Mammary gland
Membrane initiated signaling
Paracrine signals
Stem cells
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
11 03 2020
11 03 2020
Historique:
received:
05
07
2019
accepted:
06
02
2020
pubmed:
27
2
2020
medline:
22
10
2020
entrez:
27
2
2020
Statut:
epublish
Résumé
17β-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ERα. ERα acts as a transcription factor but also elicits rapid signaling through a fraction of ERα expressed at the membrane. Here, we have used the C451A-ERα mouse model mutated for the palmitoylation site to understand how ERα membrane signaling affects mammary gland development. Although the overall structure of physiological mammary gland development is slightly affected, both epithelial fragments and basal cells isolated from C451A-ERα mammary glands failed to grow when engrafted into cleared wild-type fat pads, even in pregnant hosts. Similarly, basal cells purified from hormone-stimulated ovariectomized C451A-ERα mice did not produce normal outgrowths.
Identifiants
pubmed: 32098763
pii: dev.182303
doi: 10.1242/dev.182303
pmc: PMC7075076
pii:
doi:
Substances chimiques
Estrogen Receptor alpha
0
Estradiol
4TI98Z838E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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