Novel salivary gland allergens from tropical mosquito species and IgE reactivity in allergic patients.
Allergens
IgE
Insect allergy
Mosquito
Tropical species
Journal
The World Allergy Organization journal
ISSN: 1939-4551
Titre abrégé: World Allergy Organ J
Pays: United States
ID NLM: 101481283
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
14
02
2019
revised:
29
12
2019
accepted:
15
01
2020
entrez:
27
2
2020
pubmed:
27
2
2020
medline:
27
2
2020
Statut:
epublish
Résumé
Mosquito allergy is common in tropical countries but remains under-diagnosed. This may be due to the lack of knowledge and diagnostic tools for tropical mosquito allergens. We aimed to characterize allergens from tropical mosquito species and investigate IgE reactivity in mosquito-allergic patients to the salivary gland proteins from these mosquitoes. Salivary gland extract (SGE) from 4 mosquito species, highly distributed in the tropics, including Mosquito-allergic subjects have detectable serum IgE to SGE derived from local mosquito species, while the IgE levels to Five novel allergens from 3 tropical mosquito species were characterized. The majority of mosquito-allergic subjects who live in the tropics have IgE reactivity to these allergens. Our study paves the way for the development of diagnostic tests, component-resolved diagnostics, and future immunotherapy for mosquito allergy in tropical countries.
Sections du résumé
BACKGROUND
BACKGROUND
Mosquito allergy is common in tropical countries but remains under-diagnosed. This may be due to the lack of knowledge and diagnostic tools for tropical mosquito allergens.
OBJECTIVE
OBJECTIVE
We aimed to characterize allergens from tropical mosquito species and investigate IgE reactivity in mosquito-allergic patients to the salivary gland proteins from these mosquitoes.
METHODS
METHODS
Salivary gland extract (SGE) from 4 mosquito species, highly distributed in the tropics, including
RESULTS
RESULTS
Mosquito-allergic subjects have detectable serum IgE to SGE derived from local mosquito species, while the IgE levels to
CONCLUSIONS & CLINICAL RELEVANCE
CONCLUSIONS
Five novel allergens from 3 tropical mosquito species were characterized. The majority of mosquito-allergic subjects who live in the tropics have IgE reactivity to these allergens. Our study paves the way for the development of diagnostic tests, component-resolved diagnostics, and future immunotherapy for mosquito allergy in tropical countries.
Identifiants
pubmed: 32099589
doi: 10.1016/j.waojou.2020.100099
pii: S1939-4551(20)30002-8
pii: 100099
pmc: PMC7031643
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100099Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
Authors declared no conflict of interest.
Références
Pediatrics. 2006 Jul;118(1):e189-96
pubmed: 16751615
J Dermatol. 1989 Oct;16(5):341-7
pubmed: 2600271
Ann Allergy Asthma Immunol. 2004 Dec;93(6):553-6
pubmed: 15609764
PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2507
pubmed: 24205420
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3728-33
pubmed: 19234127
J Allergy Clin Immunol. 1998 Apr;101(4 Pt 1):498-505
pubmed: 9564803
Ann Allergy Asthma Immunol. 1996 Nov;77(5):371-6
pubmed: 8933775
Ann Allergy Asthma Immunol. 2017 Jun;118(6):710-718
pubmed: 28434865
Nucleic Acids Res. 2019 Jul 2;47(W1):W636-W641
pubmed: 30976793
Int Immunol. 2001 Dec;13(12):1445-52
pubmed: 11717185
Ann Allergy Asthma Immunol. 1996 Sep;77(3):238-44
pubmed: 8814051
Allergy. 2016 May;71(5):621-8
pubmed: 26608594
Allergol Immunopathol (Madr). 2010 Jul-Aug;38(4):197-202
pubmed: 20227159
Proteomics. 2005 Sep;5(14):3765-77
pubmed: 16127729
Proc Natl Acad Sci U S A. 2014 May 13;111(19):6946-51
pubmed: 24778255
J Infect Dis. 2018 Jun 5;218(1):7-15
pubmed: 29617849
J Allergy Clin Immunol. 1999 Sep;104(3 Pt 1):705-7
pubmed: 10482852
Elife. 2015 Jun 30;4:e08347
pubmed: 26126267
Int Arch Allergy Immunol. 2016;170(1):46-56
pubmed: 27355916
J Allergy Clin Immunol. 1994 Nov;94(5):902-6
pubmed: 7525679
Clin Exp Allergy. 1996 Jun;26(6):703-9
pubmed: 8809428
Allergy. 2006 Apr;61(4):485-90
pubmed: 16512811
Allergy. 2001 Aug;56(8):787
pubmed: 11488677
PLoS One. 2011;6(12):e29107
pubmed: 22195000
Int Arch Allergy Immunol. 2019;179(2):89-101
pubmed: 30904917
Proteomics. 2007 Sep;7(18):3384-94
pubmed: 17849406
Ann Med. 1994 Aug;26(4):301-6
pubmed: 7946248
Ann Allergy Asthma Immunol. 2013 Feb;110(2):65-9
pubmed: 23352522
Int Arch Allergy Immunol. 2016;170(3):206-10
pubmed: 27603527
Clin Exp Allergy. 2018 Oct;48(10):1354-1363
pubmed: 29992665
Allergy. 2017 Oct;72(10):1499-1509
pubmed: 28235135
Curr Opin Allergy Clin Immunol. 2007 Aug;7(4):350-4
pubmed: 17620829
Asian Pac J Allergy Immunol. 2017 Dec;35(4):186-190
pubmed: 28364407
Insect Biochem Mol Biol. 2002 Sep;32(9):1101-22
pubmed: 12213246
J Dermatol. 2010 Dec;37(12):1025-31
pubmed: 21083704
Parasitol Today. 1991 Oct;7(10):267-71
pubmed: 15463385
Asian Pac J Allergy Immunol. 2010 Jun-Sep;28(2-3):162-9
pubmed: 21038786