Age progression from vicenarians (20-29 year) to nonagenarians (90-99 year) among a population pharmacokinetic/pharmacodynamic (PopPk-PD) covariate analysis of propofol-bispectral index (BIS) electroencephalography.
Adult
Aged
Aged, 80 and over
Aging
/ physiology
Algorithms
Anesthesia, Intravenous
Anesthetics, Intravenous
/ administration & dosage
Computer Simulation
Consciousness Monitors
Electroencephalography
/ drug effects
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Propofol
/ administration & dosage
Prospective Studies
Reproducibility of Results
Young Adult
Age
Bispectral index
Diagnostic accuracy
Electroencephalography
Pharmacokinetic–pharmacodynamic
Statistical model
Journal
Journal of pharmacokinetics and pharmacodynamics
ISSN: 1573-8744
Titre abrégé: J Pharmacokinet Pharmacodyn
Pays: United States
ID NLM: 101096520
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
26
11
2019
accepted:
03
02
2020
pubmed:
27
2
2020
medline:
1
5
2021
entrez:
27
2
2020
Statut:
ppublish
Résumé
Pharmacokinetic/pharmacodynamic (PK/PD) modeling has made an enormous contribution to intravenous anesthesia. Because of their altered physiological, pharmacological and pathological aspects, titrating general anesthesia in the elderly is a challenging task. Eighty patients were consecutively enrolled divided by decades from vicenarians (20-29 year) to nonagenarians (90-99 year) into eight groups. Using target controlled infusion (TCI) and electroencephalographic (EEG)-derived bispectral index (BIS) we set propofol plasma concentration (C Age was significant covariate for baseline BIS effect (E We quantified and graded EEG-BIS age-progression among different age groups divided by decades. We demonstrated deeper BIS values with decades' age progression. Our data has important implications for propofol dosing. The practical information for physicians in their daily clinical practice is using propofol C European Community Clinical Trials Database EudraCT (http://eudract.emea.eu) initial trial registration number: 2011-002847-81, and subsequently registered at www.clinicaltrials.gov; trial registration number: NCT02585284. Xijing Hospital of Fourth Military Medical University ethics committee approval number 20110707-4.
Sections du résumé
BACKGROUND
Pharmacokinetic/pharmacodynamic (PK/PD) modeling has made an enormous contribution to intravenous anesthesia. Because of their altered physiological, pharmacological and pathological aspects, titrating general anesthesia in the elderly is a challenging task.
METHODS
Eighty patients were consecutively enrolled divided by decades from vicenarians (20-29 year) to nonagenarians (90-99 year) into eight groups. Using target controlled infusion (TCI) and electroencephalographic (EEG)-derived bispectral index (BIS) we set propofol plasma concentration (C
RESULTS
Age was significant covariate for baseline BIS effect (E
CONCLUSION
We quantified and graded EEG-BIS age-progression among different age groups divided by decades. We demonstrated deeper BIS values with decades' age progression. Our data has important implications for propofol dosing. The practical information for physicians in their daily clinical practice is using propofol C
CLINICAL TRIAL REGISTRY NUMBERS
European Community Clinical Trials Database EudraCT (http://eudract.emea.eu) initial trial registration number: 2011-002847-81, and subsequently registered at www.clinicaltrials.gov; trial registration number: NCT02585284. Xijing Hospital of Fourth Military Medical University ethics committee approval number 20110707-4.
Identifiants
pubmed: 32100175
doi: 10.1007/s10928-020-09678-0
pii: 10.1007/s10928-020-09678-0
doi:
Substances chimiques
Anesthetics, Intravenous
0
Propofol
YI7VU623SF
Banques de données
ClinicalTrials.gov
['NCT02585284']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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