Health education decreases incidence of hand eczema in metal work apprentices: Results of a controlled intervention study.
Adolescent
Cytokines
/ metabolism
Dermatitis, Allergic Contact
Dermatitis, Occupational
/ epidemiology
Eczema
/ chemically induced
Epidermis
/ metabolism
Female
Filaggrin Proteins
Follow-Up Studies
Hand Dermatoses
/ chemically induced
Health Education
Health Knowledge, Attitudes, Practice
Humans
Incidence
Inservice Training
Male
Metallurgy
Mutation
Occupational Exposure
/ adverse effects
Prospective Studies
Risk Factors
S100 Proteins
/ genetics
Surveys and Questionnaires
Young Adult
RRID:SCR_001905
apprentices
hand eczema
health education
intervention
metal work
occupation
prevention
work-related skin diseases
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
22
01
2020
revised:
22
02
2020
accepted:
24
02
2020
pubmed:
27
2
2020
medline:
16
3
2021
entrez:
27
2
2020
Statut:
ppublish
Résumé
Metal work apprentices (MWAs) frequently develop work-related hand eczema (HE). To evaluate the effect of health education on incidence of work-related HE in MWAs and to assess confounding factors. In a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow-ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (FLG) null mutations and an explorative genome-wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples. The 2-year and 3-year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, P < .01 and OR 3.47, 95% CI 1.88 to 6.40, P < .0001). The knowledge score was higher in unaffected MWAs (P < .05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (P < .01) and FLG mutations (P < .001). No significant associations were found regarding epidermal cytokine levels and GWAS. Health education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling.
Sections du résumé
BACKGROUND
BACKGROUND
Metal work apprentices (MWAs) frequently develop work-related hand eczema (HE).
OBJECTIVES
OBJECTIVE
To evaluate the effect of health education on incidence of work-related HE in MWAs and to assess confounding factors.
MATERIALS/METHODS
METHODS
In a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow-ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (FLG) null mutations and an explorative genome-wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples.
RESULTS
RESULTS
The 2-year and 3-year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, P < .01 and OR 3.47, 95% CI 1.88 to 6.40, P < .0001). The knowledge score was higher in unaffected MWAs (P < .05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (P < .01) and FLG mutations (P < .001). No significant associations were found regarding epidermal cytokine levels and GWAS.
CONCLUSIONS
CONCLUSIONS
Health education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling.
Substances chimiques
Cytokines
0
FLG protein, human
0
Filaggrin Proteins
0
S100 Proteins
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
350-360Subventions
Organisme : Volkswagen Foundation
ID : ZN2778
Informations de copyright
© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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