Inflammatory mediators in saliva and gingival fluid of children with congenital heart defect.
children
congenital heart defects
gingival crevicular fluid
gingivitis
inflammatory mediators
saliva
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
02
09
2019
revised:
18
01
2020
accepted:
20
02
2020
pubmed:
27
2
2020
medline:
29
10
2020
entrez:
27
2
2020
Statut:
ppublish
Résumé
(a) To compare levels of pro- and anti-inflammatory mediators in saliva and gingival crevicular fluid (GCF) in children with and without congenital heart defects (CHD cases and controls) and to test whether a systemic component exists in CHD cases by controlling for gingivitis and plaque scores. (b) To correlate the levels of pro- and anti-inflammatory mediators in GCF and saliva with plaque bacterial composition among CHD cases and controls. Whole un-stimulated saliva and GCF samples were collected (60 CHD cases, 60 controls [Sudan]) and were analysed for levels of prostaglandin E2 (PGE2), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), interleukin-1ra (IL-1ra) and interleukin-10 (IL-10) levels. These levels were correlated with the previously reported levels of four red complex bacteria. Significantly elevated levels of PGE2 and IL-1β in GCF and IL-1β and TNF-α in saliva were detected among CHD cases compared with controls. General linear model (GLM) analyses revealed that PGE2 and IL-1β levels remained significantly higher in GCF and saliva samples, respectively, among CHD cases after controlling for gingivitis and plaque score, whereas TNF-α and IL-10 levels were significantly lower in their GCF samples. Additionally, IL-1β level was significantly positively correlated to the counts of the four red complex species in their GCF. In addition to higher levels of some pro-inflammatory mediators in saliva and GCF corresponding to more gingivitis in CHD cases, also a systemic inflammatory component exists and is reflected in these two oral fluids.
Types de publication
Journal Article
Langues
eng
Pagination
1053-1061Subventions
Organisme : Universitetet i Bergen
Organisme : University of Science and Technology
Organisme : Ahmed Gasim Cardiac Centre
Informations de copyright
© 2020 The Authors. Oral Diseases published by John Wiley & Sons Ltd.
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