Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo.
Administration, Oral
Animals
Bronchoalveolar Lavage Fluid
/ chemistry
Caco-2 Cells
Cell Survival
/ drug effects
DNA Damage
Epithelial Cells
/ drug effects
Female
Humans
Inhalation Exposure
/ adverse effects
Mice, Inbred C57BL
Nanoparticles
/ chemistry
Particle Size
Surface Properties
THP-1 Cells
Titanium
/ chemistry
Agglomerates
Biological responses
Nanomaterials
Titanium dioxide
Toxicity
Journal
Particle and fibre toxicology
ISSN: 1743-8977
Titre abrégé: Part Fibre Toxicol
Pays: England
ID NLM: 101236354
Informations de publication
Date de publication:
26 02 2020
26 02 2020
Historique:
received:
23
09
2019
accepted:
06
02
2020
entrez:
27
2
2020
pubmed:
27
2
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanoparticle (NP) agglomeration and aggregation on toxicity is poorly understood although it is strongly believed that smaller the size of the NPs greater the toxicity. A toxicologically relevant definition of NMs is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, we assessed the influence of NP agglomeration on their toxicity/biological responses in vitro and in vivo. We tested two TiO Agglomeration of TiO
Sections du résumé
BACKGROUND
The terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanoparticle (NP) agglomeration and aggregation on toxicity is poorly understood although it is strongly believed that smaller the size of the NPs greater the toxicity. A toxicologically relevant definition of NMs is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, we assessed the influence of NP agglomeration on their toxicity/biological responses in vitro and in vivo.
RESULTS
We tested two TiO
CONCLUSION
Agglomeration of TiO
Identifiants
pubmed: 32101144
doi: 10.1186/s12989-020-00341-7
pii: 10.1186/s12989-020-00341-7
pmc: PMC7045370
doi:
Substances chimiques
titanium dioxide
15FIX9V2JP
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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