In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis.
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
10
09
2019
accepted:
22
01
2020
entrez:
27
2
2020
pubmed:
27
2
2020
medline:
23
9
2020
Statut:
epublish
Résumé
Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.
Identifiants
pubmed: 32101153
doi: 10.1186/s13567-020-00744-6
pii: 10.1186/s13567-020-00744-6
pmc: PMC7045558
doi:
Substances chimiques
Anticestodal Agents
0
Indazoles
0
6-Aminonicotinamide
329-89-5
lonidamine
U78804BIDR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29Subventions
Organisme : National Natural Science Foundation of China (CN)
ID : 81171632
Organisme : the Fundamental Research Funds for the Central Universities
ID : lzujbky-2018-90
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