Cladosins L-O, new hybrid polyketides from the endophytic fungus Cladosporium sphaerospermum WBS017.
Acinetobacter baumannii
/ drug effects
Animals
Anti-Bacterial Agents
/ chemistry
Antifungal Agents
/ chemistry
Antineoplastic Agents
/ chemistry
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cladosporium
/ chemistry
Density Functional Theory
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enterococcus faecalis
/ drug effects
Mice
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis
/ drug effects
Polyketides
/ chemistry
Pseudomonas aeruginosa
/ drug effects
Saccharomyces cerevisiae
/ drug effects
Staphylococcus aureus
/ drug effects
Structure-Activity Relationship
Ustilago
/ drug effects
Antimicrobial activities
Cladosporium sphaerospermum
Cytotoxicity
Electronic circular dichroism
Hybrid polyketide
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Apr 2020
01 Apr 2020
Historique:
received:
18
11
2019
revised:
17
02
2020
accepted:
17
02
2020
pubmed:
27
2
2020
medline:
5
11
2020
entrez:
27
2
2020
Statut:
ppublish
Résumé
The endophytic fungus Cladosporium sphaerospermum WBS017 was obtained from healthy bulbs of Fritillaria unibracteata var. wabuensis. Fermentation of C. sphaerospermum on solid rice medium yielded three new hybrid polyketides, cladosins L-N (1-3), and a known derivative cladodionen (4). Further cultivation of this fungus on white bean medium afforded an additional new hybrid polyketide, cladosin O (5) along with three known analogues (6-8). The structures of the new compounds were elucidated using a combination of NMR and HRESIMS data. The absolute configurations of compounds 2 and 3 were determined by Mosher's method and TDDFT-ECD calculations. All isolated compounds were evaluated for their cytotoxic and antimicrobial activities. Cladodionen (4) exhibited cytotoxicity against the mouse lymphoma cell line L5178Y with an IC
Identifiants
pubmed: 32101782
pii: S0223-5234(20)30126-4
doi: 10.1016/j.ejmech.2020.112159
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Antineoplastic Agents
0
Polyketides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112159Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.